Research Project
Grant-in-Aid for Young Scientists (B)
Recently it was reported that the expression of CRTC1-MAML2 or CRTC3-MAML2 fusion was found on 40-70% of mucoepidermoid carcinoma. These fusions are becoming the important prognostic marker gene for MEC. We analyzed the positive cases to the fusions that include suspicious cases for histopathological diagnoses. We show the data has improved the diagnostic accuracy of MEC. We analyze the fusions clusters related to bad prognosis group and also protein and RNA related to the cell cycle/tumor suppressor gene/epithelial differentiation. Thus we would like to evaluate the downstream of fusions target genes.