Research Project
Grant-in-Aid for Young Scientists (B)
Several experiment using biochemical experiments have suggested that protein phosphatase 6 (PP6) functions at cell cycle check point, suppresses NFkB signaling, and also functions in DNA repair. However, whether PP6 is involved in carcinogenesis has not been examined. We previously reported that deficiency in the gene encoding the catalytic subunit of protein phosphatase 6 (Ppp6c) predisposes mouse skin tissue to papilloma formation initiated by DMBA. Then, we demonstrated that Ppp6c loss acts as a tumor promoter in UVB-induced basal cell carcinogenesis. Importantly, somatic mutations in Ppp6c gene have been identified in approximately 10% of malignant melanoma patients harboring Braf or Nras mutations. In this experiment, we found that induction of double mutation (Ppp6c deficiency and KrasG12D expression) in the cytokeratin 14 positive cells drives cell proliferation, and leaded to hyperplasia of squamous epithelium tissue.
All 2016 2015
All Journal Article (3 results) (of which Peer Reviewed: 3 results, Open Access: 2 results, Acknowledgement Compliant: 2 results) Presentation (2 results)
Mechanisms of Development
Volume: 139 Pages: 1-9
10.1016/j.mod.2016.02.001
Oncogene
Volume: 印刷中 Issue: 35 Pages: 4647-55
10.1038/onc.2014.398
Cancer Lett.
Volume: 365 Issue: 2 Pages: 223-228
10.1016/j.canlet.2015.05.022
