| Project/Area Number |
15K20238
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Miyagi Prefectural Hospital Organization Miyagi Cancer Center |
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Principal Investigator |
IMAI TAKAYUKI 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療開発研究部, 特任研究員 (80408583)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUURA Kazuto 地方独立法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療開発研究部, 特任研究員 (70271947)
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| Research Collaborator |
TANAKA Nobuyuki 地方独立法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療開発研究部, 部長 (60280872)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | CD271 / 頭頸部癌 / 頭頚部外科学 / 癌幹細胞 |
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| Outline of Final Research Achievements |
To determine a potential role of CD271 in a squamous cell carcinoma, CD271 was knock-downed by shRNA. CD271 mRNA knockdown inhibited both cell proliferation and migration. p42/44Erk inhibition as well as RhoA inhibition ameliorated the malignant phenotypes of hypopharyngeal HPCM2 cells. An anti-CD271 Ab, however, did not show a significant in vitro effect on the cells. Taken together, CD271 is shown to be a potential target for squamous cell carcinoma therapy.
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