The Receptor-Associated Prorenin System Is Associated with the Molecular Pathogenesis of Human Conjunctival Lymphoma
| Project/Area Number |
15K20241
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Hokkaido University |
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Principal Investigator |
Ando Ryo 北海道大学, 大学病院, 医員 (60399847)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 眼細胞生物学 / レニン・アンジオテンシン系 / 結膜リンパ腫 / （プロ）レニン受容体 / 受容体結合プロレニン系 |
|---|
| Outline of Final Research Achievements |
Extranodal marginal zone B-cell lymphoma (EMZL) is the most common subtype of conjunctival lymphoma though its molecular mechanisms of pathogenesis are largely unknown. Here, we attempted to explore the association of the renin-angiotensin system (RAS) and (pro)renin receptor [(P)RR] in the pathogenesis of conjunctival lymphoma. Surgically removed conjunctiva EMZL samples were used for gene expression, immunohistochemical and immunofluorescence analyses of (P)RR and RAS components. The present study suggests that activation of (P)RR and AT1R is associated with the pathogenesis of conjunctival EMZL by stimulating the production of FGF2 and MMPs.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Phosphorylation of alphaB-crystallin in epiretinal membrane of human proliferative diabetic retinopathy.2016
Author(s)
Dong Y, Dong Z, Kase S, Ando R, Fukuhara J, Kinoshita S, Inafuku S, Tagawa Y, Ishizuka ET, Saito W, Murata M, Kanda A, Noda K, Ishida S
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Journal Title
Int J Ophthalmol.
Volume: 9
Pages: 1100-1105
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effect of geranylgeranylacetone on the protection of retinal ganglion cells in a mouse model of normal tension glaucoma.2016
Author(s)
Dong Z, Shinmei Y, Dong Y, Inafuku S, Fukuhara J, Ando R, Kitaichi N, Kanda A, Tanaka K, Noda K, Harada T, Chin S, Ishida S.
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Phosphorylation of alphaB-crystallin in epiretinal membrane of human proliferative diabetic retinopathy2016
Author(s)
Dong Y, Dong Z, Kase S, Ando R, Fukuhara J, Kinoshita S, Inafuku S, Tagawa Y, Ishizuka ET, Saito W, Murata M, Kanda A, Noda K, Ishida S
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Journal Title
Int J Ophthalmol
Volume: in press
Related Report
Peer Reviewed
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