| Project/Area Number |
15K20243
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Research Collaborator |
YOSHIDA Akitoshi
NAGAOKA Taiji
YOKOTA Harumasa
MATSUMOTO Chiemi
KAWABE Junichi
KIMURA Shoji
|
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | Ninjurin1 / 血管新生 / 糖尿病網膜症 / マイクログリア / 接着因子 / BV-2 / 高酸素負荷モデル / 未熟児網膜症 / CXCR3 / Cre-loxP / Cre-LoxP |
|---|
| Outline of Final Research Achievements |
Diabetic retinopathy is a leading cause of blindness. Microglia are deeply involved in the pathology of diabetic retinopathy. Although, much of the mechanism remains unknown. This study aimed to investigate the pathogenesis of diabetic retinopathy targeting the role of Ninjurin1, an adhesion factor, in microglia that play an important role in retinal neovascularization. Our observations suggested that Ninjurin1 in microglia had a different role during physiological and pathological retinal neovascularization.
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