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Study for neuroprotective treatment for glaucoma using anti-calpain peptide

Research Project

Project/Area Number 15K20245
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionHirosaki University

Principal Investigator

Kudo Takashi  弘前大学, 医学部附属病院, 助教 (20598718)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords緑内障 / 正常眼圧緑内障 / GLAST ノックアウトマウス / カルパイン / GLASTノックアウトマウス / 光干渉断層計 / 神経節細胞死 / 神経保護 / ミトコンドリアカルパイン
Outline of Final Research Achievements

The purpose of this study was originally to investigate the effect of anti-mitochondrial calpain-1 peptide on glaucomatous neuronal damage in the GLAST knockout (KO) mice, which is known to be a type of normal tension glaucoma. Although the study delayed because of weak fertility of the GLAST KO mice, we established the longitudinal change in the retinal layer thickness using optical coherent tomography.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (5 results)

  • [Journal Article] Macular edema associated with intraocular ointment after cataract surgery2018

    • Author(s)
      Kudo A, Kudo T, Takahashi D, Metoki T, Suzuki Y, Nakazawa M
    • Journal Title

      American Journal of Ophthalmology Case Reports

      Volume: 10 Pages: 152-156

    • DOI

      10.1016/j.ajoc.2018.02.027

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of childfood vitrectomy to a dense vitreous hemorrhage secondary to leukemia therapy and tumor lysis syndrome2014

    • Author(s)
      Kudo T, Suzuki Y, Metoki T, Nakazawa M
    • Journal Title

      Case Reports in Ophthalmology

      Volume: 6 Issue: 1 Pages: 2015-2015

    • DOI

      10.1159/000374088

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 死亡例1例を含むステロイド治療によりニューモシスチス肺炎を併発した3症例2017

    • Author(s)
      工藤孝志、江目孝幸、田名部玲子、目時友美、工藤朝香、鈴木幸彦、中澤 満
    • Organizer
      第121回日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2017-04-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 糖尿病網膜症に対する汎網膜光凝固術既往の有無による硝子体サイトカイン濃度の差2017

    • Author(s)
      鈴木幸彦、安達功武、工藤孝志、鈴木香、目時友美、中澤 満
    • Organizer
      第121回日本眼科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 眼球二重穿孔4例の治療経験2017

    • Author(s)
      鈴木幸彦、髙橋 静、田名部玲子、毛内奈津姫、安達功武、鈴木 香、工藤孝志、中澤 満
    • Organizer
      第56回日本網膜硝子体学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 血管新生緑内障の治療方針の検討2016

    • Author(s)
      工藤孝志、安達功武、吹田淑子、山内宏大、丹藤利夫、工藤朝香、 目時友美、中澤 満
    • Organizer
      第33回日本眼循環学会
    • Place of Presentation
      アクロス福岡(福岡県、福岡市)
    • Year and Date
      2016-07-22
    • Related Report
      2016 Research-status Report
  • [Presentation] 眼内レンズ毛様溝縫着術における術中術後合併症の検討2015

    • Author(s)
      田名部玲子、鈴木幸彦、髙橋 静、毛内奈津姫、陳内嘉浩、工藤孝志、吹田淑子、中澤 満
    • Organizer
      第69回日本臨床眼科学会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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