Study for neuroprotective treatment for glaucoma using anti-calpain peptide
| Project/Area Number |
15K20245
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Hirosaki University |
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Principal Investigator |
Kudo Takashi 弘前大学, 医学部附属病院, 助教 (20598718)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 緑内障 / 正常眼圧緑内障 / GLAST ノックアウトマウス / カルパイン / GLASTノックアウトマウス / 光干渉断層計 / 神経節細胞死 / 神経保護 / ミトコンドリアカルパイン |
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| Outline of Final Research Achievements |
The purpose of this study was originally to investigate the effect of anti-mitochondrial calpain-1 peptide on glaucomatous neuronal damage in the GLAST knockout (KO) mice, which is known to be a type of normal tension glaucoma. Although the study delayed because of weak fertility of the GLAST KO mice, we established the longitudinal change in the retinal layer thickness using optical coherent tomography.
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Report
(4 results)
Research Products
(7 results)
