| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Recently, our lab clarified that trehalose has an inhibitory effect on proliferation of fibroblasts and vascular endothelial cells whereas it has a protective effect on surface epithelial cells. In this study, we tried to investigate whether or not trehalose has an inhibitory effect on growth of fibroblasts by vitreous fluid obtained from various intraocular diseases, including proliferative diabetic retinopathy. I employed cultured ARPE-19 cell in the collagen gel with or without trehalose. There was no statistical deference between gels containing trehalose and gels without trehalose in terms of shrinkage of ARPR-19 collagen gels with vitreous fluid.
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