Adaptive optics scanning laser ophthalmoscope for retinal vein occlusion-associated macular edema

• Project/Area Number: 15K20254
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Kyoto University
• Principal Investigator: Muraoka Yuki 京都大学, 医学研究科, 特定病院助教 (00739089)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 網膜循環疾患 / 黄斑浮腫 / 網膜静脈閉塞症 / 網膜循環評価 / 補償光学レーザー検眼鏡 / 赤血球凝集体速度 / AO-SLO / 凝集赤血球速度

Outline of Final Research Achievements

In the current study, I have observed affected macular lesion of eyes with retinal vein occlusion using adaptive optics scanning laser ophthalmoscopy (AO-SLO). The AO-SLO enabled quantitative measurement of the aggregated erythrocyte velocity in the parafoveal capillary network. Additionally, the aggregated erythrocyte velocity was found to strongly associate with the central foveal thickness of eyes with retinal vein occlusion. The current findings suggest that the AO-SLO evaluated erythrocyte velocity in the parafoveal capillary network would be useful for investigating for pathology of the macular edema, and prognosing for the treatment effect.

Research Products

• [Journal Article] ASSOCIATIONS BETWEEN MACULAR EDEMA AND CIRCULATORY STATUS IN EYES WITH RETINAL VEIN OCCLUSION: An Adaptive Optics Scanning Laser Ophthalmoscopy Study. (2017)
  • Author(s): Iida Y, Muraoka Y, Uji A, Ooto S, Murakami T, Suzuma K, Tsujikawa A, Arichika S, Takahashi A, Miwa Y, Yoshimura N.
  • Journal Title: Retina Volume: 印刷中 Issue: 10 Pages: 1896-1904
  • DOI: 10.1097/iae.0000000000001433
  • Peer Reviewed
• [Presentation] 補償光学を用いた網膜微小循環の観察 (2017)
  • Author(s): 宇治彰人
  • Organizer: 日本眼科学会
  • Place of Presentation: 東京
  • Year and Date: 2017-04-06
  • Invited
• [Presentation] 網膜静脈閉塞症の黄斑部における中心窩形態と網膜微小循環動態との関連 (2015)
  • Author(s): 飯田悠人、村岡勇貴、大音壮太郎、宇治彰人、高橋綾子、三輪裕子、有近重太、村上智昭、鈴間潔、辻川明孝、吉村長久
  • Organizer: 第54回日本網膜硝子体学会総会 第32回日本眼循環学会 合同学会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2015-12-05
• [Presentation] Association between Foveal Pathomorphology and Microcirculatory Status in Eyes with Retinal Vein Occlusion-Associated Macular Edema (2015)
  • Author(s): Yuto Iida, Yuki Muraoka, Sotaro Ooto, Akihito Uji, Ayako Takahashi, Yuko Miwa, Shigeta Arichika, Tomoaki Murakami, Kiyoshi Suzuma, Akitaka Tsujikawa, Nagahisa Yoshimura
  • Organizer: American Academy Ophthalmology 2015 Annual Meeting
  • Place of Presentation: Las Vegas, United States
  • Year and Date: 2015-11-14
  • Int'l Joint Research