| Project/Area Number |
15K20255
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Kyoto University |
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Principal Investigator |
Hata Masayuki 京都大学, 臨床研究総合センター, 助教 (70748269)
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| Research Collaborator |
IKEDA Hanako 京都大学, 医学部附属病院臨床研究総合センター, 准教授
MURAOKA Yuki 京都大学, 大学院医学研究科眼科学, 助教
HASEGAWA Tomoko 京都大学, 大学院医学研究科眼科学, 大学院生
KAKIZUKA Akira 京都大学, 生命科学研究科 高次生体統御学, 教授
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 虚血性眼疾患 / 神経保護薬 / VCPタンパク / ATPase / 神経保護治療 |
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| Outline of Final Research Achievements |
In this study, we investigated the neuroprotective effects of VCP ATPase inhibitor for ischemic eye diseases. We showed that the VCP modulator exerts a profound anti-apoptotic effect on ischemic retinal injury by suppressing ER stress, resulting in morphological and functional neuroprotection. Our findings may provide a novel therapeutic strategy for the treatment of neural ischemic diseases.
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