The effect of chronic long electrical stimulation by artificial vision

• Project/Area Number: 15K20258
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Osaka University
• Principal Investigator: NISHIDA KENTARO 大阪大学, 医学系研究科, 助教 (70624229)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 人工視覚 / 電気刺激

Outline of Final Research Achievements

We established the chronic long electrical stimulation system with measuring system of evoked potentials in visual cortex for artificial vision. We could stimulated the optic nerve electrode for 8 hours a day for 2 weeks and VEPs and ERGs was unchanged. Our result suggests the safety of chronic long electrical stimulation in visual system.

Academic Significance and Societal Importance of the Research Achievements

人工視覚は世界中で研究され、一部の人工視覚は実用化され視機能の回復も現実のものとなっている。人工視覚を日常的に使うようになった際に用いる慢性長時間連続通電の影響を、動物を用いて検討することは有意義であり、今回、長時間通電できるシステムを開発し、慢性長時間連続通電の影響を電気生理学的に検討した。これまでに、脊髄損傷症例に対して電気刺激とリハビリテーションにより、機能回復することが報告されているように、今後、人工視覚で用いる電気刺激自体による効果が評価できる実験系が確立できた。

Research Products

• [Journal Article] Electrophysiological evaluation of a chronically implanted electrode for suprachoroidal transretinal stimulation in rabbit eyes (2019)
  • Author(s): Nishida Kentaro、Sakaguchi Hirokazu、Kamei Motohiro、Saito Toru、Fujikado Takashi、Nishida Kohji
  • Journal Title: Journal of Artificial Organs Volume: 印刷中 Issue: 3 Pages: 237-245
  • DOI: 10.1007/s10047-019-01095-6
  • Peer Reviewed
• [Journal Article] One-Year Outcome of 49-Channel Suprachoroidal-Transretinal Stimulation Prosthesis in Patients With Advanced Retinitis Pigmentosa. (2016)
  • Author(s): Fujikado T, Kamei M, Sakaguchi H, Kanda H, Endo T, Hirota M, Morimoto T, Nishida K, Kishima H, Terasawa Y, Oosawa K, Ozawa M, Nishida K.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 57(14) Issue: 14 Pages: 6147-6157
  • DOI: 10.1167/iovs.16-20367
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Surgical feasibility and biocompatibility of wide-field dual-array suprachoroidal-transretinal stimulation prosthesis in middle-sized animals. (2016)
  • Author(s): LohmanTK, Kanda H, Morimoto T, Endo T, MiyoshiT, Nishida K, Kamei M, Walter P, Fujikado T
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 254 Issue: 4 Pages: 661-673
  • DOI: 10.1007/s00417-015-3104-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Visual Sensation by Electrical Stimulation Using a New Direct Optic Nerve Electrode Device (2015)
  • Author(s): Nishida K, Sakaguchi H, Kamei M, Gonzalez C, Terasawa Y, Montoya R, Fujikado T, Fontan R, Ozawa M, Mercardo H, Nishida K
  • Journal Title: Brain Stimul. Volume: 8 Issue: 3 Pages: 678-681
  • DOI: 10.1016/j.brs.2015.03.001
  • Peer Reviewed
• [Presentation] The characteristics of the phosphenes elicited by Artificial Vision by Direct Optic Nerve Electrical stimulation (AV-DONE). (2017)
  • Author(s): Nishida K, Sakaguchi H, Kamei M, Cecilia-Gonzalez C, Terasawa V, Velez-Montoya R, Fujikado T, Sanchez-Fontan R, Ozawa M, Quiroz-Mercado H, Nishida K
  • Organizer: 2nd International Brain Stimulation Conference
  • Place of Presentation: バルセロナ（スペイン）
  • Year and Date: 2017-03-05
  • Int'l Joint Research
• [Presentation] The color of the phosphenes elicited by Artificial Vision by Direct Optic Nerve Electrical stimulation (AV-DONE). (2017)
  • Author(s): Nishida K, Sakaguchi H, Kamei M, Terasawa Y, Fujikado T, Nishida K
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Presentation] ３Dイメージングを用いた人工視覚システムの評価 (2016)
  • Author(s): 西田健太郎、坂口裕和、瓶井資弘、不二門尚、西田幸二
  • Organizer: 第55回日本網膜硝子体学会総会
  • Place of Presentation: 東京
  • Year and Date: 2016-12-02
• [Presentation] 脈絡膜上経網膜電気刺激での電極の諸条件が大脳皮質誘発電位に与える影響の検討 (2016)
  • Author(s): 西田健太郎、坂口裕和、瓶井資弘、不二門尚、西田幸二
  • Organizer: 第70回 日本臨床眼科学会総会
  • Place of Presentation: 京都
  • Year and Date: 2016-11-03
• [Presentation] The shape of the phosphenes elicited by Artificial Vision by Direct Optic Nerve Electrical stimulation(AV-DONE). (2016)
  • Author(s): Nishida K, Sakaguchi H, Kamei M, Terasawa Y, Fujikado T, Nishida K
  • Organizer: The 9th The Eye and The Chip World Research Congress
  • Place of Presentation: デトロイト（アメリカ合衆国）
  • Year and Date: 2016-09-18
  • Int'l Joint Research
• [Presentation] The effect of electrode conditions for surprachoroidal-transretinal stimulation system on electrically-evoked potentials. (2016)
  • Author(s): Nishida K, Sakaguchi H, Kamei M, Fujikado T, Nishida K
  • Organizer: Neuroscience 2016
  • Place of Presentation: サンディエゴ（アメリカ合衆国）
  • Year and Date: 2016-09-18
  • Int'l Joint Research
• [Presentation] Visual sensation by optic nerve electrical stimulation. (2016)
  • Author(s): Nishida K
  • Organizer: 2nd International Brain Stimulation Conference
  • Place of Presentation: 北京（中華人民共和国）
  • Year and Date: 2016-05-20
  • Int'l Joint Research / Invited
• [Presentation] Visual sensation by optic nerve electrical stimulation (2016)
  • Author(s): Nishida K
  • Organizer: Neurotalk2016
  • Place of Presentation: 北京（中華人民共和国）
  • Year and Date: 2016-05-20
  • Int'l Joint Research / Invited
• [Presentation] 人工視覚の現状と未来 (2015)
  • Author(s): 西田健太郎
  • Organizer: 第54回日本網膜硝子体学会総会・第32回日本眼循環学会 合同学会
  • Place of Presentation: 東京
  • Year and Date: 2015-12-04
• [Presentation] Visual Sensation by Electrical Stimulation Using a New Direct Optic Nerve Electrode Device (2015)
  • Author(s): Nishida K, Sakaguchi H, Kamei M, Cecilia-Gonzalez C, Terasawa V, Velez-Montoya R, Fujikado T, Sanchez-Fontan R, Ozawa M, Quiroz-Mercado H, Nishida K
  • Organizer: American Society of Retina Specialists 33rd Annual Meeting
  • Place of Presentation: ウィーン（オーストリア）
  • Year and Date: 2015-07-10
  • Int'l Joint Research
• [Presentation] Suprachoroidal Stimulation Approach to Visual Prosthetics (2015)
  • Author(s): Nishida K
  • Organizer: The 30th Asia-Pacific Academy of Ophthalmology Congress
  • Place of Presentation: 広州（中華人民共和国）
  • Year and Date: 2015-04-01
  • Int'l Joint Research / Invited