Persistent Intracellular Signaling Pathway as a Promising Therapeutic Target for Retinopathy of Prematurity
| Project/Area Number |
15K20260
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 血管新生 / 内皮細胞 / 細胞内シグナル伝達分子 / 網膜 / 細胞内シグナル伝達 / VEGF |
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| Outline of Final Research Achievements |
Retinopathy of prematurity (ROP) is a vision-threatening disease in the retina of premature infants with incomplete retinal vascularization. In ROP, retinal vascular development stops and subsequently disorganized, fragile and leaky blood vessels grow. It has been studied that VEGF plays a critical role in the development of ROP. However, it remains unknown how endothelial cells alter responses to identical VEGF signaling in the growth of abnormal blood vessels. Here, we focused on long-lasting VEGF stimulation to reflect pathological condition, which induced persistent phosphorylation of Akt in cultured endothelial cells. Retinal blood vessels were dilated and leaky by the activation of Akt signaling pathway with transgenic mice. Therefore, molecules regulating persistent Akt activation can be potential targets for the treatment of ROP.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown2017
Author(s)
Ogura S, Kurata K, Hattori Y, Takase H, Ishiguro-Oonuma T, Hwang Y, Ahn S, Park I, Ikeda W, Kusuhara S, Fukushima Y, Nara H, Sakai H, Fujiwara T, Matsushita J, Ema M, Hirashima M, Minami T, Shibuya M, Takakura N, Kim P, Miyata T, Ogura Y, Uemura A
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Journal Title
JCI Insight
Volume: 2
Issue: 3
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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