| Project/Area Number |
15K20264
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
MORITA Yukiko 山口大学, 医学(系)研究科(研究院), 助教 (30725669)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 生体分子 / 医療・福祉 |
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| Outline of Final Research Achievements |
In FY2005, we clarified that CsnB inhibits the action of TGF-β by gel shrinkage experiment. Expression of αSMA was also confirmed using cultured human corneal stromal cells (HKC). In TGF-β-stimulated HKC, αSMA was expressed abundantly, and TGF-β + CsnB stimulated cells showed only slight expression of αSMA compared to HGF with only TGF-β stimulation, and CsnB induced apoptosis of keratocyte And inhibited the transdifferentiation into myofibroblasts. In FY2008, scar suppression by CsnB and LY 215 7299 was evaluated using a corneal incisional wound model, but reproducibility was not obtained in the results.
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