Pathology of age-related macular degeneration using polarized RPE cells
| Project/Area Number |
15K20270
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Kagoshima University |
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Principal Investigator |
Terasaki Hiroto 鹿児島大学, 医歯学総合研究科, 客員研究員 (20746888)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 加齢黄斑変性 / 網膜色素上皮細胞 / 血管内皮細胞増殖因子 |
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| Outline of Final Research Achievements |
Effects of anti-vascular endothelial growth factor(VEGF) on polarized RPE cells were studied. All of these drugs did not affect cellular toxicity or barrier function in polarized RPE cells. However, we found that there were differences of anti-VEGF effect and permeability between drugs in polarized RPE cells. These results suggested that we might be able to clarify the choice of anti-VEGF drugs based upon clinical findings.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] PERMEABILITY AND ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR EFFECTS OF BEVACIZUMAB, RANIBIZUMAB, AND AFLIBERCEPT IN POLARIZED RETINAL PIGMENT EPITHELIAL LAYER IN VITRO.2017
Author(s)
Yoshihara N, Terasaki H, Shirasawa M, Kawano H, Sonoda S, Yamakuchi M, Hashiguchi T, Hisatomi T, Ishibashi T, Sakamoto T.
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Journal Title
Retina
Volume: 37(1)
Issue: 1
Pages: 179-190
DOI
Related Report
Peer Reviewed
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