Search for the non-invasive fundus imaging modality based on melanin-related autofluorescence.
| Project/Area Number |
15K20273
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 網膜 / 非侵襲 / イメージング / 近赤外 / 早期発見 / 予防医学 / 加齢黄斑変性 / 低侵襲 / メラニン / 自発蛍光 |
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| Outline of Final Research Achievements |
During the period, we elucidated the following. 1) We revealed the significant association between the clinical subtypes of wet age-related macular degeneration (AMD) and the choroidal vessel shadow seen on near-infrared fundus autofluorescence (NIR-FAF). Choroidal vessel shadow may indirectly reflect the integrity of retinal pigment epithelium (RPE). 2) NIR-FAF can detect the prodromal AMD change such as soft drusen or RPE degeneration earlier than the conventional shortwave fundus autofluoreccence (SW-FAF). NIR-FAF is thought to be of value in detection of the AMD change. 3) Drusenoid pigment epithelial detachment (drusenoid PED) is known as the prodromal stage of dry AMD. We found the early RPE degeneration already occurs at the clinical onset of drusenoid PED. 4) We tried the 3 view angles of 30, 55, 102 degrees of NIR-FAF, and found that NIR-FAF images of 55 degrees are valuable in the clinical use.
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Report
(3 results)
Research Products
(3 results)
