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Search for the non-invasive fundus imaging modality based on melanin-related autofluorescence.

Research Project

Project/Area Number 15K20273
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Yamagishi Tetsuya  京都府立医科大学, 医学部附属病院, 専攻医 (40733572)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords網膜 / 非侵襲 / イメージング / 近赤外 / 早期発見 / 予防医学 / 加齢黄斑変性 / 低侵襲 / メラニン / 自発蛍光
Outline of Final Research Achievements

During the period, we elucidated the following. 1) We revealed the significant association between the clinical subtypes of wet age-related macular degeneration (AMD) and the choroidal vessel shadow seen on near-infrared fundus autofluorescence (NIR-FAF). Choroidal vessel shadow may indirectly reflect the integrity of retinal pigment epithelium (RPE). 2) NIR-FAF can detect the prodromal AMD change such as soft drusen or RPE degeneration earlier than the conventional shortwave fundus autofluoreccence (SW-FAF). NIR-FAF is thought to be of value in detection of the AMD change. 3) Drusenoid pigment epithelial detachment (drusenoid PED) is known as the prodromal stage of dry AMD. We found the early RPE degeneration already occurs at the clinical onset of drusenoid PED. 4) We tried the 3 view angles of 30, 55, 102 degrees of NIR-FAF, and found that NIR-FAF images of 55 degrees are valuable in the clinical use.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2016 2015

All Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] drusenoid PEDの各種画像所見2016

    • Author(s)
      山岸哲哉
    • Organizer
      第55回日本網膜硝子体学会総会
    • Place of Presentation
      ベルサール渋谷ガーデン
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] Near-infrared fundus autofluorescence of the unaffected fellow eyes of patients with unilateral exudative age-related macular degeneration2016

    • Author(s)
      山岸哲哉
    • Organizer
      ARVO 2016 Annual Meeting
    • Place of Presentation
      Washington state convention center
    • Year and Date
      2016-05-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 滲出型加齢黄斑変性の臨床所見と近赤外自発蛍光所見との関連2015

    • Author(s)
      山岸哲哉
    • Organizer
      第54回 日本網膜硝子体学会総会/第32回日本眼循環学会 合同学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2015-12-04
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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