| Project/Area Number |
15K20275
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Nakai Yoshinori 京都府立医科大学, 医学部附属病院, 専攻医 (10727910)
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| Research Collaborator |
Tanaka Hiroshi
Ueno Morio 京都府立医科大学, 医学部附属病院, 講師
Takahiko Sato 京都府立医科大学, 眼科, 特任助教
Ikeya Makoto 京都大学, iPS細胞研究所, 准教授
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 多能性幹細胞 / 神経冠細胞 / 角膜内皮細胞 / ヒト多能性幹細胞 / 神経堤細胞 / 細胞移植 / 神経堤細胞の分化誘導 / 誘導細胞の維持培養 / ノックインiPS細胞 |
|---|
| Outline of Final Research Achievements |
Results of this study suggested that the human neural crest cells induced from human ES/iPS cells. Possessed the characteristics of cranial neural crest cells, which exhibit the potential to differentiate into corneal endothelial cells. This simple, robust, and chemically defined induction protocol enables to generate neural crest cells as an intermediate material producing terminally differentiate cells for cell-based innovative medicine.
In the future, this study will provide a highly practical system for inducing corneal endothelium from human ES/iPS cells.
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