Role of SIRT3 in age-related retinal diseases

• Project/Area Number: 15K20284
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Keio University
• Principal Investigator: Uchida Atsuro 慶應義塾大学, 医学部(信濃町), 特任助教 (70365336)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 網膜 / 老化 / 光 / 酸化ストレス / ミトコンドリア / 長寿遺伝子 / SIRT3

Outline of Final Research Achievements

SIRT3 knock out mice showed no obvious phenotype in the retina until 60 weeks old. However, they showed more severe light induced retinal degeneration compared with wild type mice. The levels of reactive oxygen species were higher and mitochondria had abnormality detected by electron microscopy after light exposure in the knock out mice.

Research Products

• [Journal Article] Distinct responsiveness to intravitreal ranibizumab therapy in polypoidal choroidal vasculopathy with single or multiple polyps. (2016)
  • Author(s): Suzuki M, Nagai N, Shinoda H, Uchida A, Kurihara T, Tomita Y, Kamoshita M, Iyama C, Tsubota K, Ozawa Y
  • Journal Title: American Journal of Ophthalmology Volume: 166 Pages: 52-59
  • DOI: 10.1016/j.ajo.2016.03.024
  • Peer Reviewed / Open Access
• [Journal Article] Non-responsiveness to intravitreal aflibercept treatment in neovascular age-related macular degeneration: implications of serous pigment epithelial detachment. (2016)
  • Author(s): Nagai N, Suzuki M, Uchida A, Kurihara T, Kamoshita M, Minami S, Shinoda H, Tsubota K, Ozawa Y.
  • Journal Title: Sci Rep. Volume: 11 Issue: 1 Pages: 29619-29619
  • DOI: 10.1038/srep29619
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Functional Visual Acuity in Age-Related Macular Degeneration. (2016)
  • Author(s): Tomita Y, Nagai Y, Suzuki M, Shinoda H, Uchida A, Mochimaru H, Izumi-Nagai K, Sasaki M, Tsubota K, Ozawa Y
  • Journal Title: Optometry and Vision Science Volume: 93 Issue: 1 Pages: 70-76
  • DOI: 10.1097/opx.0000000000000755
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association of macular pigment optical density with serum concentration of oxidized low-density lipoprotein in healthy adults. (2015)
  • Author(s): Nagai N, Izumi-Nagai K, Suzuki M, Shinoda H, Koto T, Uchida A, Mochimaru H, Tomita Y, Miyake S, Kobayashi S, Sasaki M, Tsubota K, Ozawa Y.
  • Journal Title: Retina Volume: 35(4) Issue: 4 Pages: 820-826
  • DOI: 10.1097/iae.0000000000000382
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Wide-Angle Viewing System versus Conventional Indirect Ophthalmoscopy for Scleral Buckling. (2015)
  • Author(s): Tomita Y, Kurihara T, Uchida A, Nagai N, Shinoda H, Tsubota K, Ozawa Y
  • Journal Title: Scientific Reports Volume: 5:13256 Issue: 1 Pages: 1-7
  • DOI: 10.1038/srep13256
  • Peer Reviewed / Open Access
• [Presentation] 漿液性網膜色素上皮剥離を合併する加齢黄斑変性に対するアフリベルセプト (2016)
  • Author(s): 永井紀博，鈴木美砂，南早紀子，内田敦郎，栗原俊英，鴨下衛，篠田肇，坪田一男，小沢洋子
  • Organizer: 第70回日本臨床眼科学会
  • Place of Presentation: 国立京都国際会館・グランドプリンスホテル京都（京都府京都市）
  • Year and Date: 2016-11-03
• [Presentation] ポリープ上脈絡膜血管症に対するアフリベルセプト硝子体内注射の効果の解析 (2016)
  • Author(s): 南早紀子，永井紀博，鈴木美砂，栗原俊英，鴨下衛，内田敦郎，篠田肇，坪田一男，小沢洋子
  • Organizer: 第70回日本臨床眼科学会
  • Place of Presentation: 国立京都国際会館・グランドプリンスホテル京都（京都府京都市）
  • Year and Date: 2016-11-03
• [Presentation] Predictive factors for non-response to intravitreal aflibercept treatment in neovascular age-related macular degeneration. (2016)
  • Author(s): Nagai N, Suzuki M, Uchida A, Kurihara T, Kamoshita M, Minami S, Shinoda H, Tsubota K, Ozawa Y.
  • Organizer: The Association for Research in Vision and Ophthalmology
  • Place of Presentation: シアトル（アメリカ）
  • Year and Date: 2016-05-01
  • Int'l Joint Research
• [Presentation] 視力良好な滲出型加齢黄斑変性に対するアフリベルセプト硝子体内注射の前向き研究 (2016)
  • Author(s): 南早紀子，永井紀博，鈴木美砂，栗原俊英，鴨下衛，内田敦郎，篠田肇，坪田一男，小沢洋子
  • Organizer: 第120回日本眼科学会総会
  • Place of Presentation: 仙台国際センター・東北大学百周年記念会館（宮城県仙台市）
  • Year and Date: 2016-04-07
• [Presentation] 加齢黄斑変性に対するアフリベルセプト投与無効症例の予測因子 (2015)
  • Author(s): 永井紀博、鈴木美砂、持丸博史、富田洋平、内田敦郎、栗原俊秀、井山千草、鴨下衛、篠田肇、坪田一男、小沢洋子.
  • Organizer: 第54回日本網膜硝子体学会総会
  • Place of Presentation: 東京国際フォーラム (東京都千代田区)
  • Year and Date: 2015-12-04
• [Presentation] 網膜中心静脈閉塞症に対するアフリベルセプト及びラニビズマブの9か月間の治療成績. (2015)
  • Author(s): 栗原俊英、清水裕介、永井紀博、鈴木美砂、内田敦郎、篠田肇、坪田一男、小沢洋子
  • Organizer: 第54回日本網膜硝子体学会総会
  • Place of Presentation: 東京国際フォーラム (東京都千代田区)
  • Year and Date: 2015-12-04
• [Presentation] 眼内レンズ脱臼に対する眼内レンズ縫着術の術後成績の検討. (2015)
  • Author(s): 佐藤真理、鴨下衛、永井紀博、内田敦郎、井山千草、篠田肇、小沢洋子、坪田一男.
  • Organizer: 第69回日本臨床眼科学会
  • Place of Presentation: 名古屋国際会議場 (愛知県名古屋市)
  • Year and Date: 2015-10-22
• [Presentation] Wide-Angle Viewing System versus Conventional Indirect Ophthalmoscopy for Scleral Buckling. (2015)
  • Author(s): Tomita Y, Kurihara T, Uchida A, Nagai N, Shinoda H, Tsubota K, Ozawa Y.
  • Organizer: The16th Congress of the European Retina, Macula and Vitreous Society
  • Place of Presentation: Nice, France
  • Year and Date: 2015-09-17
  • Int'l Joint Research