Role of SIRT3 in age-related retinal diseases
| Project/Area Number |
15K20284
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Keio University |
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Principal Investigator |
Uchida Atsuro 慶應義塾大学, 医学部(信濃町), 特任助教 (70365336)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 網膜 / 老化 / 光 / 酸化ストレス / ミトコンドリア / 長寿遺伝子 / SIRT3 |
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| Outline of Final Research Achievements |
SIRT3 knock out mice showed no obvious phenotype in the retina until 60 weeks old. However, they showed more severe light induced retinal degeneration compared with wild type mice. The levels of reactive oxygen species were higher and mitochondria had abnormality detected by electron microscopy after light exposure in the knock out mice.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Association of macular pigment optical density with serum concentration of oxidized low-density lipoprotein in healthy adults.2015
Author(s)
Nagai N, Izumi-Nagai K, Suzuki M, Shinoda H, Koto T, Uchida A, Mochimaru H, Tomita Y, Miyake S, Kobayashi S, Sasaki M, Tsubota K, Ozawa Y.
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Journal Title
Retina
Volume: 35(4)
Issue: 4
Pages: 820-826
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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