Visual cortex plasticity study in visual impairment patients with non invasive brain stimulation method
| Project/Area Number |
15K20289
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 白質 / 拡散強調MRI / 加齢黄斑変性 / Tractography / White matter / Diffusion MRI / TMS / 視覚再建 / MRI / ナビゲーションシステム / 脳可塑性 |
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| Outline of Final Research Achievements |
We would investigate visual cortex plasticity study in visual impairment patients with non invasive brain stimulation method. The patients could not accept their brain stimulation. It was difficult to value the phosphene even in normals and the phosphene was not replicable.We investigated the impact of age-related macular degeneration (AMD) on visual acuity and the visual white matter. We combined an adaptive cortical atlas and diffusion-weighted magnetic resonance imaging (dMRI) and tractography to separate optic radiation (OR) projections to different retinal eccentricities in human primary visual cortex. We found differences in white matter properties specific to OR white matter fascicles projecting to primary visual cortex locations corresponding to the location of retinal damage (fovea).
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| Academic Significance and Societal Importance of the Research Achievements |
加齢黄斑変性患者の脳白質は網膜変性の影響を受ける可能性が示唆された。さらに視野偏心度ごとに脳白質を解析することで、視力障害と相関して白質線維の変化をきたしているであろう解剖学的位置も特定することができた。これらの結果は昨今期待が高まっているiPS細胞などを用いた視覚再建治療の際に、その治療の適応や治療効果判定の際のターゲットとなる可能性が示唆された。網膜変性が脳白質まで影響を及ぼした場合、その治療が網膜再建のみで良いのか、脳白質を含めた視路の再建も必要であるのかを検討する必要があると考えられた。
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Report
(5 results)
Research Products
(2 results)
