Role of ICOS on Corneal Lymphangiogenesis

• Project/Area Number: 15K20290
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Nippon Medical School
• Principal Investigator: Kunishige Tomoyuki 日本医科大学, 医学部, 助教 (60516045)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: ICOS / 血管新生 / 免疫学 / 副刺激分子シグナル / 副刺激シグナル

Outline of Final Research Achievements

Interaction between the inducible costimulatory molecule (ICOS) and its ligand, B7-related protein (B7RP-1), has been reported to have an impact on differentiation and functions of various T regulatory cells. The purpose of the present study is to further investigate the role of ICOS on inflammatory lymphoangiogeneisis in the cornea and its mechanisms.

Research Products

• [Journal Article] Protective role of ICOS and ICOS Ligand in corneal transplantation and in maintenance of immune privilege (2016)
  • Author(s): Kunishige T, Taniguchi H, Terada M, Akiba H, Yagita H, Abe R, Hori J
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 57(15) Issue: 15 Pages: 6815-6823
  • DOI: 10.1167/iovs.16-20644
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 角膜移植後免疫応答にみる眼内微小環境の特殊性 (2016)
  • Author(s): 國重智之 堀純子
  • Journal Title: 医学のあゆみ Volume: 256 Pages: 1259-1961
• [Presentation] Expression of ICOS and Foxp3 on T cells infiltrating in corneal allografts (2016)
  • Author(s): Hiroko Taniguchi, Kunishige Tomoyuki, Hisaya Akiba, Hideo Yagita, Abe, Ryo, Junko Hori
  • Organizer: Association for Research in Vision and Ophthalmology (ARVO) 016
  • Place of Presentation: Seattle, WA, USA
  • Int'l Joint Research
• [Presentation] マウス角膜移植におけるICOS/ICOS-Lの役割 (2015)
  • Author(s): 國重智之, 谷口ヒロ子, 大野建州, 東みゆき, 堀純子
  • Organizer: Tokyo Ocular immunology meeting
  • Place of Presentation: 東京
  • Year and Date: 2015-09-11
• [Presentation] Mechanisms of V-domain Ig suppressor of T cell activation (VISTA)-mediated acceptance of corneal allografts. (2015)
  • Author(s): Tomoyuki Kunishige, H Taniguchi, T Ohno, M Azuma, J Hori.
  • Organizer: ARVO
  • Place of Presentation: Denver, CO, USA
  • Year and Date: 2015-05-06
• [Remarks] 日本医科大学眼科 研究業績
  • URL: http://www2.nms.ac.jp/nms/ganka/achievements/original.html