| Project/Area Number |
15K20292
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 眼瞼圧 / ドライアイ / 甲状腺眼症 / 眼窩減圧術 / 顔面神経麻痺 / マイボーム腺 |
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| Outline of Final Research Achievements |
The aim of this study was to compare the eyelid pressure and dry eye severity before and 3 months after orbital decompression in patients with thyroid eye disease and between affected and unaffected sides in patients with unilateral facial nerve palsy. In patients with thyroid eye disease, eyelid pressure decreased and the morphology of the Meibomian gland and its orifices improved postoperatively. These results suggest that orbital decompression surgery reduced eyelid pressure, leading to improvement in Meibomian gland function. In patients with facial nerve palsy, eyelid pressure was lower and the tear meniscus height was higher on the affected side. These results indicate that low eyelid pressure decreased lacrimal pump function, leading to a high tear meniscus height. Although low eyelid pressure aggravates dry eye, a high tear meniscus height may offset it.
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