| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
Gastrointestinal motility disorders are intractable disease which may not be able to acquire sufficient defecation function only by surgery. We have reported the usefulness of cell transplantation therapy using enteric neural crest cells to this condition. Based on the results, we examined the effectiveness of the therapeutic effect using dental pulp cells as a clinically accessible neural crest cells. Transplanted cells were visualized and transplanted into model mice to observe engraftment of the transplanted cells for several month after cell transplantation. Although engraftment of the transplanted cells could be confirmed, histological observation of the transplanted cells was difficult, and the differentiation ability could not be evaluated. Based on the difference in growth and maintenance method between gut derived neural crest cells and dental pulp cells, it is necessary to evaluate thier differentiation potential.
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