Development of an autologous valved conduit (Biovalve) with small diameter for children: Enhancement of tissue formation for subcutaneously-implanted molds
| Project/Area Number |
15K20305
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatric surgery
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| Research Institution | Osaka Prefecture University (2016)
National Cardiovascular Center Research Institute (2015) |
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Principal Investigator |
Funayama Marina 大阪府立大学, 生命環境科学研究科, 客員研究員 (30713599)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 小児外科学 / 人工弁 / 小児心臓弁移植 / 医療 / 心臓血管外科 / 組織工学 / 肺動脈弁 |
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| Outline of Final Research Achievements |
Pediatric patients with congenital heart disease would benefit from replacement heart valves, particularly pulmonic valves. We developed an autologous valved conduit (Biovalve), formed by in-body tissue architecture technology (IBTA) using subcutaneously embedded plastic molds. Excellent hemodynamic performance and beneficial leaflet movement after implantation were observed in experimental models. However, in particular Bivalves with small diameter had thin conduit wall thickness, requiring careful handling. We aimed at development of Biovalves with robust and thick conduits wall. The paling structure facilitated the formation of approximately 1-mm thick conduit wall and leaflets through a small aperture inside the inner portion. The paling mold was highly effective in constructing a robust, completely autologous Biovalves with adequate valve function.
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Report
(3 results)
Research Products
(4 results)
