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Basic research on gene therapy using HGF gene plasmid in free adipose tissue transplantation

Research Project

Project/Area Number 15K20312
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Plastic surgery
Research InstitutionThe University of Tokushima

Principal Investigator

MINEDA Kazuhide  徳島大学, 病院, 特任助教 (70747815)

Research Collaborator HORIKAWA Hidemasa  
MISAWA Shigeo  
TSUDA Tatsuya  
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords遊離脂肪移植 / HGF遺伝子プラスミド / HGF遺伝子プラスミド
Outline of Final Research Achievements

As a basic research on gene therapy using HGF gene plasmid in free adipose tissue transplantation, an experiment was conducted in an animal model. As a result, there was no significant difference in atrophy rate of transplanted free fat at 3 months after transplantation. However, qualitative evaluation by immunostaining revealed that it inhibited the necrosis of adipocytes in the HGF gene plasmid introduced group. Further verification such as genetic analysis and protein analysis is necessary in the future, but suppression of necrosis of transplanted fat clinically can lead to the prevention of cyst formation and calcification known as late complications, I believe that clinical application can be expected especially in fat injection technique in breast.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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