| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Bioactive proteins, such as laminin, were reported that has an agiogenesis effect. Skin flap was raised on the back of rat, and a sheet conteining bioactive protein was placed on the wound in order to extend survival area of the skin flap. Both its angiogenesis and extending effect, however, were not clear. Survival area of the skin flaps are roughly corresponding to its perfusion area.
Then, a U-shaped skin flap was raised on the back of rat, and survival area of the skin flap was carefully observed by preserving blood vessels selectively. In bipedicle flap, 2 to 2.5 perfusion area from each vascular pedicle has limitations on survival. Additional blood vessels preserved at the center of this flap, seemed to be developing stability in the 2.5 perfusion area from vascular pedicle, even though they were cut in the second operation.
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