| Project/Area Number |
15K20321
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Keio University |
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Principal Investigator |
Takada Keiko 慶應義塾大学, 医学部(信濃町), 助教 (80624460)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | fetal / mice / Wnt / wound / Ｗｎｔ / 創傷治癒 / 皮膚 / 胎仔 / 再生 |
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| Outline of Final Research Achievements |
By using mice fetal wound healing model, we made cutaneous wounds at various developmental stages of mice fetuses. Then the relationship between the expression of Wnt signaling and wound healing was observed. It was shown that in embryonic (E)13 wounds, no Wnt signals were over expressed. But when the wounds were made at later developmental stages, Wnt signals including Wnt 3a, 5, 10 and so on were over expressed at the margin of the wounds. From these results, it was supposed that the scarring and over expression of Wnt signals are co-related.
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