| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We have reported the therapeutic effects of skeletal muscle-derived multipotent stem cells (Sk-Cs) which exerted reconstitution capacity for muscle-nerve-blood vessel unit. The aim of this study is the application of Sk-Cs transplantation system to the reconstitution of facial complex nerve-vascular networks after severe damaged. The mice experiments were performed as the histological analysis and the rats were used for functional examinations. The transplanted group showed significantly higher functional score as compared to the Control group. In support, engrafted transplanted cells formed nerve-vascular networks with the differentiation into Schwann and perineurial cells, vascular endothelial and smooth muscle cells. Thus, the Sk-Cs sheet pellet transplantation is potentially useful for the reconstitution of the complex facial nerve-vascular networks.
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