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Exploration of lymphatic vessel regeneration mechanism by artificial lymph node transfer

Research Project

Project/Area Number 15K20330
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Plastic surgery
Research InstitutionChiba University

Principal Investigator

Shinsuke Akita  千葉大学, 医学部附属病院, 助教 (00436403)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsリンパ浮腫 / リンパ節移植 / リンパ管新生 / 人工リンパ節 / 人工リンパ管 / リンパ管細静脈吻合 / リンパ浮腫モデル / 新生リンパ管
Outline of Final Research Achievements

No lymphangiogenesis and newly developed lymphatic flow into the artificial lymph node were observed. The cause of this result was thought to be a scar formation before newly developed blood circulation was established. A pedicled vascularized lymph node transfer model was developed using abdominal lymphedema model mice. Lymphangiogenesis and afferent lymphatic flow into the transferred lymph node was investigated using this model mice. Newly developed lymphatic flow was observed in some cases and was not observed in others, despite adequate blood flow was confirmed. For establishing afferent lymphatic flow into the transferring lymph node, it seemed to be very important to avoid forming a scar around the transferring lymph node.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2017

All Presentation (4 results)

  • [Presentation] Rabbit 耳介を用いたリンパ浮腫モデルを用いたlymphatic microsurgery2017

    • Author(s)
      秋田新介
    • Organizer
      第41回日本リンパ学会
    • Place of Presentation
      鹿児島医師会館(鹿児島県・鹿児島市)
    • Year and Date
      2017-06-02
    • Related Report
      2016 Research-status Report
  • [Presentation] リンパ浮腫の評価の低侵襲化2017

    • Author(s)
      秋田新介
    • Organizer
      第60回日本形成外科学会総会
    • Place of Presentation
      大阪国際会議場(大阪府・大阪市)
    • Year and Date
      2017-04-12
    • Related Report
      2016 Research-status Report
  • [Presentation] Rabbit Ear Lymphedema Modelを用いたリンパ管細静脈吻合と血管柄付きリンパ節移植の比較2017

    • Author(s)
      秋田新介
    • Organizer
      第26回日本形成外科学会基礎学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] リンパ浮腫非侵襲評価方法の確立と侵襲的定量評価方法の開発2017

    • Author(s)
      秋田新介
    • Organizer
      第44回日本マイクロサージャリー学会
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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