| Project/Area Number |
15K20339
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 腸内フローラ / マルチオミクス手法 / 免疫応答 / IgA / メタボローム解析 / 水素 / 重症病態 / 敗血症 / メタゲノム / メタボローム / 分子状水素 / 全身性炎症症候群 / 腸管免疫 |
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| Outline of Final Research Achievements |
Microbiota composition is altered in the critical illnesss, leading to dysregulated intestinal or systemic immune responses. However, the mechanism is not well established. We aimed to analyze the interaction between gut microbiota, metabolite and intestinal immune response with integrative omics approach in a murine model of sepsis. We revealed the rapid and dynamic alterations of gut microbiota, metabolite in murine septic mice. In particular, the dramatic overgrowth of Enterobacteriaceae, which was specifically combined with sIgA, would be a key bacteria for therapeutic strategy. Furthermore, we found the potential effect of hydrogen-rich saline with improving the survival rate and attenuating the overgrowth of Enterobacteriaceae.
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