| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
BU has strong anti-inflammatory effects, which are not correlated with NFκB activation. BU has two distinct actions in association with anti-inflammatory effects: weak inhibition of LPS-induced STAT1 phosphorylation and IRF1 expression, and suppression of mitochondrial activities, leading to reduced iATP levels. Because the combination of rotenone and filgotinib suppressed NO release to a similar extent as BU, the marked anti-inflammatory effects of BU could be attributable to the synergistic effects of JAK1 inhibition and reduction in iATP. The mechanism behind BU’s effects on iATP contents and JAK1 activity remains to be clarified with future research.
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