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Differential diagnosis of fever using canonical discriminant analysis of innate immune receptor gene expression profiles

Research Project

Project/Area Number 15K20346
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Emergency medicine
Research InstitutionNagasaki University

Principal Investigator

TAJIMA Goro  長崎大学, 病院(医学系), 助教 (00437427)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords自然免疫受容体 / 全身性炎症 / 判別分析 / 発熱 / 感染症
Outline of Final Research Achievements

Infection in patients with systemic inflammation is difficult to diagnose with a single biomarker. We aimed to clarify the time course of change in the gene expression profile of innate immune receptors in infectious or sterile inflammation and to establish an early diagnostic method using canonical discriminant analysis (CDA) of the gene expression profile.
Using murine peritonitis model and burn injury models, we compared the expression pattern of innate immune receptors. In the CDA, each group showed distinctive gene expression patterns at just 6 hours after injury. Each group was clearly classified, and the classification error rates were 0% at all of the time points. CDA of the gene expression profile of innate immune receptors could be a novel approach for diagnosing the pathophysiology of complicated systemic inflammation from the early stage of injury.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Early diagnosis using canonical discriminant analysis of innate immune receptor gene expression profiles in a murine infectious or sterile systemic inflammation model2018

    • Author(s)
      Tajima Goro、Tokunaga Ayako、Umehara Takahiro、Ikematsu Kazuya、Miyamoto Junya、Sato Shuntaro、Tasaki Osamu
    • Journal Title

      Journal of Trauma and Acute Care Surgery

      Volume: 84 Issue: 4 Pages: 583-589

    • DOI

      10.1097/ta.0000000000001789

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] EARLY DIAGNOSIS USING CANONICAL DISCRIMINANT ANALYSIS OF INNATE IMMUNE RECEPTOR GENE EXPRESSION PROFILE IN INFECTIOUS OR STERILE SYSTEMIC INFLAMMATION2017

    • Author(s)
      田島吾郎
    • Organizer
      76th Annual Meeting of AAST and Clinical Congress of Acute Care Surgery
    • Place of Presentation
      Baltimore(USA)
    • Year and Date
      2017-09-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] EARLY DIAGNOSIS USING CANONICAL DISCRIMINANT ANALYSIS OF INNATE IMMUNE RECEPTOR GENE EXPRESSION PROFILE IN INFECTIOUS OR STERILE SYSTEMIC INFLAMMATIONl2017

    • Author(s)
      Goro Tajima
    • Organizer
      76th Annual Meeting of AAST and Clinical Congress of Acute Care Surgery
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 全身性炎症における自然免疫受容体発現パターンによる早期病態判別法2017

    • Author(s)
      田島 吾郎
    • Organizer
      日本救急医学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 第44回 日本救急医学会総会2016

    • Author(s)
      田島吾郎
    • Organizer
      全身性炎症における自然免疫受容体発現パターンによる感染症診断法
    • Place of Presentation
      グランドプリンスホテル新高輪・国際館パミール(東京都港区)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Research-status Report
  • [Presentation] INFECTION DIAGNOSIS IN SYSTEMIC INFLAMMATION BY INNATE IMMUNE RECEPTOR EXPRESSION PATTERN2016

    • Author(s)
      田島吾郎
    • Organizer
      75th Annual Meeting of AAST and Clinical Congress of Acute Care Surgery
    • Place of Presentation
      Waikoloa(USA)
    • Year and Date
      2016-09-14
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Infection Diagnosis in Systemic inflammation by Innate Immune Receptor Expression Pattern2016

    • Author(s)
      田島吾郎
    • Organizer
      75th Annual Meeting of AAST and Clinical Congress of Acute Care Surger
    • Place of Presentation
      Waikoloa, HI USA
    • Year and Date
      2016-09-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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