| Project/Area Number |
15K20348
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 敗血症性心機能障害 / ミトコンドリア機能障害 / 亜硝酸塩 / 一酸化窒素 / 心保護作用 / ストレス応答 |
|---|
| Outline of Final Research Achievements |
Recently, the cardioprotective effect of nitrite has been reported, but the effects of nitrite in sepsis is unknown. In this study, we administered nitrite to rats with severe sepsis model by cecal ligation and puncture, and examined its cardioprotective effect and safety. We elucidated that 1mg / kg of nitrite improved a cardiac contractility and myocardial mitochondrial function. Furthermore, in vivo hemodynamic, blood inflammatory cytokines, and myocardial nitrating stress were not exacerbated by nitrite. Nitrite administration also significantly improved the survival rate of septic rats. In the present study, our results showed a potential of nitrite for cardioprotection in severe sepsis.
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