| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
We elucidated a mechanism of exacerbation mechanism of sepsis during acute ethanol intoxication in view of pentraxin 3 (PTX3) production. PTX3 is an acute phase protein, whose levels increase rapidly in response to inflammation. PTX3 production is triggered by TNF-α and is mediated by JNK phosphorylation. As PTX3 exerts protective effects on endothelial barrier integrity, it mitigates acute lung injury during sepsis.
We demonstrated that ethanol suppresses de novo PTX3 synthesis via two mechanisms; suppression of TNF-α production and inhibition of JNK phosphorylation.
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