• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The role of macrophage SOCS3 in cardiac remodeling after myocardial infarction.

Research Project

Project/Area Number 15K20355
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Emergency medicine
Research InstitutionKurume University

Principal Investigator

Nohara Shoichiro  久留米大学, 医学部, 助教 (20647812)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords急性心筋梗塞 / SOCS3 / サイトカイン / 梗塞後リモデリング / マクロファージ / 心破裂
Outline of Final Research Achievements

The purpose of this study is to clarify the role of macrophage SOCS3 in acute myocardial infarction.Macrophage specific SOCS3-KO(SOCS-mKO) mice had high mortality more than control mice. This result suggests that macrophage SOCS3 has protective effect for myocardium after myocardial infarction. LV rupture rate after myocardial infarction was high in the SOCS3-mKO mice than in the control mice.Third day after myocardial infarction, myocardium internal hemorrhage was greater in SOCS3-mKO mice than in the control mice. We will evaluate MMP to clarify the mechanism of LV rupture.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 2015

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (7 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Renal Nerve- Mediated Erythropoietin Release Confers Cardioprotection During Remote Ischemic Preconditioning.2015

    • Author(s)
      Oba T, Yasukawa H, Nagata T, Kyogoku S, Minami T, Nishihara M, Ohshima H, Mawatari K, Nohara S, Takahashi J, Sugi Y, Igata S, Iwamoto Y, Kai H, Matsuoka H, Takano M, Aoki H, Fukumoto Y, Imaizumi T.
    • Journal Title

      Circulation Journal

      Volume: 79 Pages: 1557-1567

    • NAID

      130005083944

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardiac- Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules2015

    • Author(s)
      Takanobu Nagata Hideo Yasukawa Sachiko Kyogoku Toyoharu Oba Jinya Takahashi Shoichiro Nohara Tomoko Minami Kazutoshi Mawatari Yusuke Sugi Koutatsu Shimozono Sylvain Pradervand Masahiko Hoshijima Hiroki Aoki Yoshihiro Fukumoto Tsutomu Imaizumi
    • Journal Title

      PLoS One

      Volume: 26

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] サイトカインシグナルの制御と心不全の病態 『特集 心不全の最近の話題』2015

    • Author(s)
      安川 秀雄、野原 正一郎、高橋 甚彌、福本 義弘
    • Journal Title

      循環器内科

      Volume: 1 Pages: 68-74

    • Related Report
      2015 Research-status Report
  • [Presentation] 心筋特異的SOCS3欠失マウスにおけるischemic preconditioningによる心筋虚血再還流障害の顕著な抑制効果2017

    • Author(s)
      野原 正一郎、永田 隆信、安川 秀雄、髙橋 甚彌、下園 弘達、佐々木 知子、柴田 龍宏、福本 義弘
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      金沢市教育プラザ此花 特設テント(金沢市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Synergistic Reduction of Myocardial Ischemia Reperfusion Injury by Ischemic Preconditioning and Myocardial SOCS3 Deficiency In Mice.2016

    • Author(s)
      Nohara S, Nagata T, Yasukawa H, Sugi Y, Mawatari K, Fukui D, Kyogoku S, Ohshima H, Minami T Takahshi J, SHimozono K, Shibata T, Fukumoto Y.
    • Organizer
      American Heart Association, The 90th Scientific Sessions
    • Place of Presentation
      New Orleans
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] 心筋特異的SOCS3欠失マウスにおけるischemic preconditioningによる心筋虚血再還流障害の顕著な抑制効果2016

    • Author(s)
      野原 正一郎、永田 隆信、安川 秀雄、髙橋 甚彌、下園 弘達、佐々木 知子、柴田 龍宏、福本 義弘
    • Organizer
      第3回iHFフォーラム
    • Place of Presentation
      ホテルオークラ東京(東京都中央区)
    • Year and Date
      2016-08-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Substantial reduction of myocardial ischemia-reperfusion injury by ischemic preconditioning in cardiac-specific SOCS3 deficient mice2016

    • Author(s)
      野原 正 一郎、安川 秀雄、永田 隆信、佐々木知子、髙橋 甚彌、下園弘達、柴田 龍宏、福本 義弘
    • Organizer
      iHFフォーラム
    • Place of Presentation
      東京
    • Year and Date
      2016-08-06
    • Related Report
      2015 Research-status Report
  • [Presentation] 心筋特異的SOCS3欠失マウスにおけるischemic preconditioningによる心筋虚血再還流障害の顕著な抑制効果2016

    • Author(s)
      野原 正一郎、永田 隆信、安川 秀雄、髙橋 甚彌、下園 弘達、佐々木 知子、柴田 龍宏、福本 義弘
    • Organizer
      第4回 Meet The Cardiologist in Hakata
    • Place of Presentation
      ホテル日航福岡(福岡市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Cardiac-Specific SOCS3 Deficiency Leads to Left Ventricular Dysfunction with Advanced Age through Impaired Autophagy2015

    • Author(s)
      Shoichiro Nohara, Hideo Yasukawa, Toyoharu Oba, Yusuke Sugi Kazutoshi Mawatari, Daisuke Fukui, Takanobu Nagata, Sachiko Kyogoku Hideki Ohshima, Tomoko Minami, Jinya Takahashi, Koutatsu Shimozono, Yoshihiro Fukumoto
    • Organizer
      American Heart Association
    • Place of Presentation
      オーランド
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cardiac-Specific SOCS3 Deficiency Leads to Left Ventricular Dysfunction with Advanced Age through Impaired Autophagy2015

    • Author(s)
      Shoichiro Nohara, Hideo Yasukawa, Toyoharu Oba, Yusuke Sugi Kazutoshi Mawatari, Daisuke Fukui, Takanobu Nagata, Sachiko Kyogoku Hideki Ohshima, Tomoko Minami, Jinya Takahashi, Koutatsu Shimozono, Yoshihiro Fukumoto
    • Organizer
      日本心不全学会
    • Place of Presentation
      大坂
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi