The role of macrophage SOCS3 in cardiac remodeling after myocardial infarction.

• Project/Area Number: 15K20355
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Kurume University
• Principal Investigator: Nohara Shoichiro 久留米大学, 医学部, 助教 (20647812)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 急性心筋梗塞 / SOCS3 / サイトカイン / 梗塞後リモデリング / マクロファージ / 心破裂

Outline of Final Research Achievements

The purpose of this study is to clarify the role of macrophage SOCS3 in acute myocardial infarction.Macrophage specific SOCS3-KO(SOCS-mKO) mice had high mortality more than control mice. This result suggests that macrophage SOCS3 has protective effect for myocardium after myocardial infarction. LV rupture rate after myocardial infarction was high in the SOCS3-mKO mice than in the control mice.Third day after myocardial infarction, myocardium internal hemorrhage was greater in SOCS3-mKO mice than in the control mice. We will evaluate MMP to clarify the mechanism of LV rupture.

Research Products

• [Journal Article] Renal Nerve- Mediated Erythropoietin Release Confers Cardioprotection During Remote Ischemic Preconditioning. (2015)
  • Author(s): Oba T, Yasukawa H, Nagata T, Kyogoku S, Minami T, Nishihara M, Ohshima H, Mawatari K, Nohara S, Takahashi J, Sugi Y, Igata S, Iwamoto Y, Kai H, Matsuoka H, Takano M, Aoki H, Fukumoto Y, Imaizumi T.
  • Journal Title: Circulation Journal Volume: 79 Pages: 1557-1567
  • NAID: 130005083944
  • Peer Reviewed / Open Access
• [Journal Article] Cardiac- Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules (2015)
  • Author(s): Takanobu Nagata Hideo Yasukawa Sachiko Kyogoku Toyoharu Oba Jinya Takahashi Shoichiro Nohara Tomoko Minami Kazutoshi Mawatari Yusuke Sugi Koutatsu Shimozono Sylvain Pradervand Masahiko Hoshijima Hiroki Aoki Yoshihiro Fukumoto Tsutomu Imaizumi
  • Journal Title: PLoS One Volume: 26
  • Peer Reviewed / Open Access
• [Journal Article] サイトカインシグナルの制御と心不全の病態 『特集 心不全の最近の話題』 (2015)
  • Author(s): 安川 秀雄、野原 正一郎、高橋 甚彌、福本 義弘
  • Journal Title: 循環器内科 Volume: 1 Pages: 68-74
• [Presentation] 心筋特異的SOCS3欠失マウスにおけるischemic preconditioningによる心筋虚血再還流障害の顕著な抑制効果 (2017)
  • Author(s): 野原 正一郎、永田 隆信、安川 秀雄、髙橋 甚彌、下園 弘達、佐々木 知子、柴田 龍宏、福本 義弘
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 金沢市教育プラザ此花 特設テント(金沢市)
  • Year and Date: 2017-03-17
• [Presentation] Synergistic Reduction of Myocardial Ischemia Reperfusion Injury by Ischemic Preconditioning and Myocardial SOCS3 Deficiency In Mice. (2016)
  • Author(s): Nohara S, Nagata T, Yasukawa H, Sugi Y, Mawatari K, Fukui D, Kyogoku S, Ohshima H, Minami T Takahshi J, SHimozono K, Shibata T, Fukumoto Y.
  • Organizer: American Heart Association, The 90th Scientific Sessions
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-12
• [Presentation] 心筋特異的SOCS3欠失マウスにおけるischemic preconditioningによる心筋虚血再還流障害の顕著な抑制効果 (2016)
  • Author(s): 野原 正一郎、永田 隆信、安川 秀雄、髙橋 甚彌、下園 弘達、佐々木 知子、柴田 龍宏、福本 義弘
  • Organizer: 第3回iHFフォーラム
  • Place of Presentation: ホテルオークラ東京(東京都中央区)
  • Year and Date: 2016-08-06
• [Presentation] Substantial reduction of myocardial ischemia-reperfusion injury by ischemic preconditioning in cardiac-specific SOCS3 deficient mice (2016)
  • Author(s): 野原 正 一郎、安川 秀雄、永田 隆信、佐々木知子、髙橋 甚彌、下園弘達、柴田 龍宏、福本 義弘
  • Organizer: iHFフォーラム
  • Place of Presentation: 東京
  • Year and Date: 2016-08-06
• [Presentation] 心筋特異的SOCS3欠失マウスにおけるischemic preconditioningによる心筋虚血再還流障害の顕著な抑制効果 (2016)
  • Author(s): 野原 正一郎、永田 隆信、安川 秀雄、髙橋 甚彌、下園 弘達、佐々木 知子、柴田 龍宏、福本 義弘
  • Organizer: 第4回 Meet The Cardiologist in Hakata
  • Place of Presentation: ホテル日航福岡(福岡市)
• [Presentation] Cardiac-Specific SOCS3 Deficiency Leads to Left Ventricular Dysfunction with Advanced Age through Impaired Autophagy (2015)
  • Author(s): Shoichiro Nohara, Hideo Yasukawa, Toyoharu Oba, Yusuke Sugi Kazutoshi Mawatari, Daisuke Fukui, Takanobu Nagata, Sachiko Kyogoku Hideki Ohshima, Tomoko Minami, Jinya Takahashi, Koutatsu Shimozono, Yoshihiro Fukumoto
  • Organizer: American Heart Association
  • Place of Presentation: オーランド
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] Cardiac-Specific SOCS3 Deficiency Leads to Left Ventricular Dysfunction with Advanced Age through Impaired Autophagy (2015)
  • Author(s): Shoichiro Nohara, Hideo Yasukawa, Toyoharu Oba, Yusuke Sugi Kazutoshi Mawatari, Daisuke Fukui, Takanobu Nagata, Sachiko Kyogoku Hideki Ohshima, Tomoko Minami, Jinya Takahashi, Koutatsu Shimozono, Yoshihiro Fukumoto
  • Organizer: 日本心不全学会
  • Place of Presentation: 大坂
  • Year and Date: 2015-10-22