| Project/Area Number |
15K20356
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Research Collaborator |
KOMORI Toshihumi 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (00252677)
ODA Kimimitsu 新潟大学, 医歯学系, 教授 (10122681)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 骨基質石灰化 / 骨芽細胞 / TNALP / 石灰化 / 骨細胞 / ENPP1 |
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| Outline of Final Research Achievements |
In order to elucidate the regulation of phosphate ion generation by chondrocyte and osteoblastic cells (preosteoblast, osteoblast and osteocyte) during the process of bone mineralization, we generated transgenic mice over-expressing tissue non-specific alkaline phosphatase (TNALP) driven by type I collagen promoter specific to preosteoblast/osteoblast, or type II collagen promoter specific to chondrocyte. We have examined the localization of several enzymes and membrane transporters involved in phosphate ion generation and mineralization in bone.
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