| Project/Area Number |
15K20363
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
SASAKI Muneteru 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (10706336)
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| Research Collaborator |
KUROSHIMA Shinichiro
AMIZUKA Norio
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨細胞 / αklotho / リン濃度 / 血中リン濃度 / αklothoタンパク |
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| Outline of Final Research Achievements |
The aim of this study was to investigate that relationship between osteocyte and phosphorous serum level. Low phosphorous diet improved the phenotype of kl/kl mice, but this diet did not improved the phenotype of α klotho-/- mice. Our finding suggests that not only phosphorous serum level but also other factors may be associated with the phenotype of α klotho-/- mice. Next, expression levels of osteocyte-related genes and proteins were investigated using osteocytes derived from mouse calvariae under various phosphorous conditions. The expression level of an osteocyte-related protein was changed in a phosphorous dose dependent manner. Hence, osteocyte may directly detect the phosphorous serum levels in the presence of α klotho protein.
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