Investigation of immune response against pathogenic fungus Candida albicans
| Project/Area Number |
15K20371
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
Nagao Jun-ichi 福岡歯科大学, 口腔歯学部, 講師 (30509047)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Candida albicans / 獲得免疫 / Th17 / 口腔カンジダ症 / 病原真菌 / Th17細胞 / 免疫応答 |
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| Outline of Final Research Achievements |
Candida albicans is the most important fungal pathogen of humans and causes oral candidiasis. T helper 17 (Th17) cells have been known to mediate protective immunity against C. albicans infection. However, little is known about the regulatory mechanism to induce Th17 immune response by C. albicans. We focused on the T-cell antigens in C. albicans to induce Th17 cells. A membrane fraction of mycelial cells effectively induced differentiation of CD4+ T cells to Th17 cells. Mycelial membrane-differentiated Th17 cells adoptive transferred intravenously prevented oral candidiasis by oral infection of C. albicans.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Antifungal activity in vitro and in vivo of a salmon protamine peptide and its derived cyclic peptide against Candida albicans.2017
Author(s)
Nagao, J., Cho, T., Mitarai, M., Iohara, K., Hayama, K., Abe, S. and Tanaka, Y.
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Journal Title
FEMS Yeast Res.
Volume: 17
Issue: 1
Pages: fow099-fow099
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Investigation of mechanisms underlying the T cell response in oral candidiasis2017
Author(s)
Tasaki Sonoko, Cho Tamaki, Nagao Jun-ichi, Narita Yuka, Hashimoto Marie, Ikezaki Shojiro, Yasumatsu Kanae, Toyoda Keita, Arita-Morioka Ken-ichi, Kojima Hiroshi, Tanaka Yoshihiko
Organizer
第46回日本免疫学会学術集会
Related Report
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