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Development of novel selective cell membrane permeable peptides targeting tongue cancer cells

Research Project

Project/Area Number 15K20376
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Functional basic dentistry
Research InstitutionUniversity of the Ryukyus

Principal Investigator

Tsumuraya Tomoyuki  琉球大学, 医学部, 委託非常勤講師 (30745279)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords細胞膜透過性ペプチド / CPP / DDS / 舌癌 / 口腔癌 / 細胞膜透過ペプチド / ドラッグデリバリーシステム / ファージディスプレイ法
Outline of Final Research Achievements

Peptide sequences specifically incorporated into HSC-3 (human tongue carcinoma cell line), SAS (human tongue carcinoma cell line) and Ca9-22 (human gingival carcinoma cell line) were searched by phage display method. Phage was concentrated by Bio panning and DNA sequencing, but no significant differences in the frequency of expression between the obtained peptides.
In order to perform in vivo screening with the searched CPP, creation of a cancer model mouse was planned. Different types of cancer cell lines were injected into multiple dorsal areas of immunodeficient mice, We created a mouse that can perform screening with high efficiency.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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