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The involvement of microglia and early molecular signaling in the jaw face of abnormal pain onset

Research Project

Project/Area Number 15K20378
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Functional basic dentistry
Research InstitutionShowa University

Principal Investigator

Han In Yang  昭和大学, 歯学部, 助教 (00712556)

Research Collaborator INOUE Tomio  昭和大学, 歯学部口腔生理学講座, 教授 (70184760)
IWATA Kouichi  日本大学, 歯学部口腔生理学講座, 教授 (60160115)
SHINODA Masamichi  日本大学, 歯学部口腔生理学講座, 准教授 (20362238)
NAKAMURA Shiro  昭和大学, 歯学部口腔生理学講座, 准教授 (60384187)
MOCHIZUKI Ayako (NAKAYAMA Kiyomi)  昭和大学, 歯学部口腔生理学講座, 助教 (10453648)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsmicroglia / 異所性異常疼痛 / 炎症 / 口腔顔面痛 / allodynia / 脊髄 / 三叉神経 / マイクログリア / 顎顔面領域 / 関連痛 / 顎顔面部領域
Outline of Final Research Achievements

In clinical practice it may be encountered in patients complaining of maxillofacial part ectopic abnormal. Cervical inflammation and damage are considered as causes.In order to elucidate the molecular mechanism associated with the onset of allodynia, an inflammatory agent was administered to create model rat.Behavioral observation was carried out for 15 days, and on day 4, ectopic abnormal pain of the maxillofacial area skin was confirmed in the model group. The decrease in pain response at an earlier stage than before the 4th day was observed. In the immunohistological study, activation of microglia was recognized in the spinal cord of dominant region of maxillofacial region skin. From the study, it was suggested that there is a possibility of signal transmission between nerve and glia in the development of pain.
Unfortunately, this study could not identify early molecular signals and would like to expect further research.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (1 results)

All 2015

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] p38 phosphorylation in medullary microglia mediates ectopic orofacial inflammatory pain in rats.2015

    • Author(s)
      Kiyomoto M, Shinoda M, Honda K, Nakaya Y, Dezawa K, Katagiri A, Kamakura S, Inoue T, Iwata K.
    • Journal Title

      Mol Pain.

      Volume: 12 Pages: 48-48

    • DOI

      10.1186/s12990-015-0053-y

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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