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Development of a combination cancer therapy utilizing oncolytic adenovirus with chemotherapy

Research Project

Project/Area Number 15K20381
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionHokkaido University

Principal Investigator

Matsuda Aya  北海道大学, 歯学研究院, 特別研究員(RPD) (60514312)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords腫瘍溶解ウイルス / 口腔がん / 抗がん剤 / 抗癌剤
Outline of Final Research Achievements

Oncolytic adenovirus is an attractive tool for cancer therapy. We developed a novel oncolytic adenovirus ( AdΔE4) based on the ARE-mRNA stabilization system. In this study, we examined the combination effect of AdΔE4 with cisplatin (CDDP). In the case of combined use of AdΔE4 with CDDP, the cell survival rate of CDDP resistant cancer cells were very lower compared with those of single treatments. These results indicate that new virus available for the combination cancer therapy with CDDP. To evaluate the mechanism of the combination effect of AdΔE4 with CDDP, we treated cancer cells by CDDP. CDDP treatment of cancer cells resulted in higher expression of HuR protein in the cytoplasm of cancer cells. These results suggest that the HuR mediated ARE-mRNA stabilization system plays an important role in AdΔE4 replication.

Report

(3 results)
  • 2017 Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report

Research Products

(16 results)

All 2017 2016 2015

All Journal Article Presentation

  • [Journal Article] Identification of marker genes required to predict oral cancer cells with intrinsic resistance to cisplatin.2017

    • Author(s)
      Kitamura T., Higashino F., Yanagawa-Matsuda A., Ueda M., Kashiwao K., Okada T., Ohiro Y., and Shindoh M.
    • Journal Title

      Oncology Letters

      Volume: 印刷中

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] ALDH1 and podoplanin expression patterns predict the risk of malignant transformation in oral leukoplakia2017

    • Author(s)
      Habiba U, Hida K, Kitamura T, Yanagawa-Matsuda A, Higashino F,Ito YM, Ohiro Y, Totsuka Y, Shindoh M
    • Journal Title

      Oncology Letter

      Volume: 13 Pages: 321-328

    • DOI
      10.3892/ol.2016.5379
    • NAID
      120006220001
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] HuR and podoplanin expression is associated with a high risk of malignant transformation in patients with oral preneoplastic lesions2016

    • Author(s)
      Habiba U., Kitamura T., Yanagawa-Matsuda A., Higashino F., Hida K., Totsuka Y. and Shindoh M.
    • Journal Title

      Oncology Letters

      Volume: 12 Pages: 3199-3207

    • DOI
      10.3892/ol.2016.5061
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] HuR and podoplanin expression is correlated with high risk of malignant transformation in patients with oral preneoplastic lesions.2016

    • Author(s)
      Habiba U., Hida K., Higashino F., Kitamura T., Yanagawa-Matsuda A., Totsuka Y. and Shindoh M.
    • Journal Title

      Oncology Letters

      Volume: 印刷中

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Conditionally replicative adenovirus controlled by the stabilization system of AU-rich elements containing mRNA.2017

    • Author(s)
      Mikawa Y., Kitamura T., Yanagawa-Matsuda A., Kitagawa Y, Shindoh M., Higashino F
    • Organizer
      3rd International Conference on Oral and Maxillofacial Syrgery
    • Place of Presentation
      Hong Kong, China
    • Year and Date
      2017-03-31
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of oncolytic adenovirus controlled by the stabilization system of AU-rich element containing mRNA2016

    • Author(s)
      Matsuda A, Mikawa Y, Kitamura T, Yasuda M, Higashino F, Shindoh M
    • Organizer
      第64 回日本ウイルス学会学術総会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-10-23
    • Related Report
      2016 Research-status Report
  • [Presentation] AU-rich element を持つmRNA 安定化機構で制御される新しい腫瘍溶解アデノウイルス2016

    • Author(s)
      柳川-松田 彩、東野史裕、北村哲也、進藤正信
    • Organizer
      第27 回日本臨床口腔病理学会
    • Place of Presentation
      広島大学
    • Year and Date
      2016-08-10
    • Related Report
      2016 Research-status Report
  • [Presentation] Cancer therapy by combining oncolytic adenovirus with anticancer drug、2016

    • Author(s)
      Habiba U, Kitamura T, Yanagawa-Matsuda A, Higashino F, Shindoh M
    • Organizer
      第27 回日本臨床口腔病理学会
    • Place of Presentation
      広島大学
    • Year and Date
      2016-08-10
    • Related Report
      2016 Research-status Report
  • [Presentation] 化学療法耐性がんに対する腫瘍溶解アデノウイルスの効果2016

    • Author(s)
      松田 彩、北村哲也、東野史裕、進藤正信
    • Organizer
      第105 回日本病理学会総会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2016-05-12
    • Related Report
      2016 Research-status Report
  • [Presentation] 口腔扁平苔癬の悪性化に関する免疫組織学的検討2016

    • Author(s)
      太田尚克、松田彩、北村哲也、東野史裕、進藤正信
    • Organizer
      第105 回日本病理学会総会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2016-05-12
    • Related Report
      2016 Research-status Report
  • [Presentation] mRNA安定化機構を利用した腫瘍溶解アデノウイルス2015

    • Author(s)
      東野史裕、三河洋平、北村哲也、柳川-松田 彩、鄭 朱蒙、進藤正信
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-10-10
    • Related Report
      2015 Research-status Report
  • [Presentation] アデノウイルス感染によるARE-mRNAの安定化2015

    • Author(s)
      鄭 朱蒙、東野史裕、北村哲也、松田 彩、進藤正信
    • Organizer
      第26回日本臨床口腔病理学会学術大会・総会
    • Place of Presentation
      北海道大学学術交流会館(札幌)
    • Year and Date
      2015-07-31
    • Related Report
      2015 Research-status Report
  • [Presentation] mRNAの安定化システムを利用した腫瘍溶解アデノウイルスの開発2015

    • Author(s)
      三河洋平、北村哲也、松田 彩、東野史裕、進藤正信
    • Organizer
      第26回日本臨床口腔病理学会学術大会・総会
    • Place of Presentation
      北海道大学学術交流会館(札幌)
    • Year and Date
      2015-07-31
    • Related Report
      2015 Research-status Report
  • [Presentation] 腫瘍溶解ウイルスとシスプラチンとの併用効果の検討2015

    • Author(s)
      稗田敏雄、三河洋平、松田 彩、北村哲也、東野史裕、進藤正信
    • Organizer
      第26回日本臨床口腔病理学会学術大会・総会
    • Place of Presentation
      北海道大学学術交流会館(札幌)
    • Year and Date
      2015-07-31
    • Related Report
      2015 Research-status Report
  • [Presentation] アデノウイルス感染によるHuRの挙動はウイルス複製と関連する2015

    • Author(s)
      松田 彩、北村哲也、東野史裕、黒嶋雄志、鄭 朱蒙、ウンマ ハビバ、進藤正信
    • Organizer
      第104回日本病理学会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-05-02
    • Related Report
      2015 Research-status Report
  • [Presentation] CD44s and CD44v6 expression in oral leukoplakia and their prognostic significance.2015

    • Author(s)
      ウンマ ハビバ、北村哲也、柳川-松田 彩、東野史裕、樋田京子、進藤正信
    • Organizer
      第104回日本病理学会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-05-02
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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