| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Oral squamous cell carcinoma (SCC) and carcinoma in-situ (CIS) frequently form the interface facing non-cancerous epithelium. I hypothesized cell competition might be occurred between cancer and non-cancerous cells in this interface. Thus, I investigated this interface histopathologically and performed proteomic analysis using LC-MS/MS. In histological analysis, apoptotic bodies, hyaline bodies, and other morphological changes suggesting cell damage were frequently observed in the cancer side adjacent to the interface. From proteomic analysis, 7 proteins, specifically increasing or decreasing in the cancer or non-cancerous sides adjacent to the interface, were identified. These proteins may be involved in cell competition between oral SCC/CIS cells and non-cancerous cells.
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