Estimation of fat fraction in the salivary glands using DIXON method: Application to Sjogren's syndrome

• Project/Area Number: 15K20386
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Aichi Gakuin University
• Principal Investigator: Kise Yoshitaka 愛知学院大学, 歯学部, 講師 (30513197)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: シェーグレン症候群 / MRI / 脂肪含有率 / 耳下腺 / 顎下腺 / DIXON法 / 唾液腺

Outline of Final Research Achievements

Fat fraction (FF) in the salivary glands of healthy subjects and patients with Sjogren 's syndrome was quantitatively evaluated using 6 point DIXON method which is imaging technique of MRI.
From this study, it was found that quantification of FF in salivary gland is possible by 6 point DIXON method. Furthermore, by using this technique, it was suggested that fat deposition occurs in the salivary glands depending on the physical characteristics and blood condition of the individual even in the normal group. In addition, in Sjogren 's syndrome patients, it was suggested that fatty degeneration was likely to occur in the submandibular glands. These results seemed to contribute to the establishment of new diagnostic methods and development of therapeutic methods for Sjogren 's syndrome in the future.

Research Products

• [Journal Article] Clinical usefulness of the mDIXON Quant the method for estimation of the salivary gland fat fraction: comparison with MR spectroscopy (2017)
  • Author(s): Kise Yoshitaka、Chikui Toru、Yamashita Yasuo、Kobayashi Koji、Yoshiura Kazunori
  • Journal Title: British Journal of Radiology Volume: 90 Issue: 1077
  • DOI: 10.1259/bjr.20160704
  • Peer Reviewed
• [Presentation] Estimation of fat fraction in the salivary glands using new MRI method (2016)
  • Author(s): Yoshitaka Kise, Toru Chikui, YasuoYamashita, Koji Kobayashi, Kazunori Yoshiura, Eiichiro Ariji
  • Organizer: The 11th Asian Congress of Oral and Maxillofacial Radiology
  • Place of Presentation: Chiang Mai, Thailand
  • Year and Date: 2016-11-10
  • Int'l Joint Research
• [Presentation] Salivary gland fat fraction estimated with a new MRI method (2015)
  • Author(s): Yoshitaka Kise, Toru Chikui, YasuoYamashita, Koji Kobayashi, Atsushi Takemura, Kazunori Yoshiura, Eiichiro Ariji
  • Organizer: International Association for Dental Research Australia and New Zealand Division Annual Scientific Meeting
  • Place of Presentation: Dunedin, New Zealand
  • Year and Date: 2015-08-23
• [Presentation] 唾液腺内脂肪含有率の測定：mDIXON QuantおよびMR spectroscopyとの比較 (2015)
  • Author(s): 木瀬祥貴、筑井徹、山下泰生、小林幸次、武村濃、吉浦一紀
  • Organizer: 日本歯科放射線学会第56回学術大会
  • Place of Presentation: 仙台市戦災復興記念館（仙台市）
  • Year and Date: 2015-06-07