Development of antibacterial self-adhesive resin cements containing chlorhexidine
| Project/Area Number |
15K20402
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Conservative dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
Kitagawa Ranna 大阪大学, 歯学部附属病院, 医員 (70711068)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | レジンセメント / 抗菌性 / クロルヘキシジン / 溶出 / 歯学 / バイオフィルム形成抑制 / 接着強さ / 曲げ強さ / 歯科材料学 / 抗菌性材料 |
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| Outline of Final Research Achievements |
In this study, the experimental self-adhesive resin cements containing chlorhexidine diacetate (CHX) at various concentrations were prepared, and their antibacterial effects, bonding ability, and physical properties were evaluated. The experimental cements prepared by incorporation of CHX at 5 (wt)% or greater into a commercial dual-cure G-CEM LinkAce (GC Corp., Tokyo) exhibited antibacterial effects at uncured stage and inhibited biofilm formation on their surfaces after curing. In addition, the experimental cement containing 5 (wt)% CHX demonstrated dentin bonding ability and flexural strength acceptable for clinical use.
Thus, incorporation of CHX at 5 (wt)% into G-CEM LinkAce was found to be a promising approach to provide the self-adhesive resin cements with antibacterial activities.
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Report
(3 results)
Research Products
(8 results)
