The study of the new adhesive which combine MMPs activity inhibitor

• Project/Area Number: 15K20404
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Conservative dentistry
• Research Institution: Kagoshima University (2016-2017); Okayama University (2015)
• Principal Investigator: HOSHIKA Tomohiro 鹿児島大学, 医歯学域歯学系, 講師 (20609953)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 象牙質 / MMPs / 接着 / MMP

Outline of Final Research Achievements

In this study, I examined influence of the MMPs activity inhibitors on mechanical properties of the decalcified dentin and the experimental bonding system that combined the MMPs activity inhibitors with bonding resin of the self-etching system. 1). Influence on mechanical property: MMPs activity inhibitors treatment improved the mechanical property of the decalcified dentin. 2)．Influence in the dentin adhesion: In early adhesion examination, there were no decline of the bonding strength the combination to bonding agents with tannic acid until 1%. In 6 months storage, tannic acid controlled degradation of the bonding strength.
Because the change of color of the tooth substance with tannic acid and Saforide were accepted, the development of the MMPs activity inhibitors which does not cause a change of color is necessary.

Research Products

• [Journal Article] Dentin Bond Strength of the Universal Adhesives using the Colloidal Platinum Nanoparticles (2017)
  • Author(s): Aiichiro KATSUMATA, Tamaki KATSUMATA, Shuhei HOSHIKA, Tomohiro HOSHIKA, Tomiko NISHITANI, Takehiro YAJIMA, Tadasu SATO, Hiroyuki ICHIKAWA, Hidehiko SANO, Yoshihiro
  • Journal Title: Journal of Oral Tissue Engineering Volume: 15 Issue: 1 Pages: 11-17
  • DOI: 10.11223/jarde.15.11
  • NAID: 130006394595
  • ISSN: 1348-9623, 1880-0823
  • Peer Reviewed / Open Access
• [Journal Article] Microtensile Bond Strength Bonded to Dentin of a Newly Universal Adhesive (2017)
  • Author(s): Aiichiro KATSUMATA, Pipop SAIKAEW, Shihchun Ting, Tamaki KATSUMATA, Tomohiro HOSHIKA, Hidehiko SANO, Yoshihiro NISHITANI
  • Journal Title: Journal of Oral Tissue Engineering Volume: 15 Issue: 1 Pages: 18-24
  • DOI: 10.11223/jarde.15.18
  • NAID: 130006394586
  • ISSN: 1348-9623, 1880-0823
  • Peer Reviewed / Open Access
• [Journal Article] 接着性修復材料の長期耐久性への検討 (2017)
  • Author(s): 星加知宏
  • Journal Title: 鹿児島大学歯学部紀要 Volume: 37 Pages: 15-19
  • NAID: 120006223700
• [Journal Article] Effect of Cell Growth on Adhesive Root Canal Sealer Containing Portlamd Cement (2017)
  • Author(s): 達山 祥子、高 裕子、勝俣 愛一郎、梶原 武弘、星加 知宏、今井 弘一、西谷 佳浩
  • Journal Title: Journal of the Japanese Association of Regenerative Dentistry Volume: 15 Issue: 1 Pages: 3-9
  • DOI: 10.11223/jard.15.3
  • NAID: 130006471220
  • ISSN: 1348-9615, 1880-0815
  • Peer Reviewed / Open Access
• [Journal Article] Mineralization of Resin Using Experimental Adhesives Containing Hydroxyapatite in Long Term. (2015)
  • Author(s): Tomohiro HOSHIKA
  • Journal Title: Journal of Oral Tissue Engineering. Volume: １３（２） Pages: 85-95
  • NAID: 130005150543
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] MMPs活性抑制効果を持つ接着システムの象牙質に対する影響について (2018)
  • Author(s): 星加知宏, 勝俣愛一郎，丁 群展，勝俣 環，西谷登美子，永山祥子，西谷佳浩
  • Organizer: 第148回日本歯科保存学会秋季学術大会
• [Presentation] Influence of tannic acid on mechanical properties of dentin and bonding strength (2018)
  • Author(s): Tomohiro Hoshika, Yoshihiro Nishitani
  • Organizer: 32th International Association for dental research south east asia division
  • Int'l Joint Research
• [Presentation] Influence of the cross-linker on mechanical properties of the decalcified dentin (2017)
  • Author(s): Tomohiro Hoshika, Aiichiro Katsumata, Chun-Chan Ting, Yoshihiro Nishitani
  • Organizer: BRAZIL - JAPAN Joint Research Workshop on Adhesive Dentistry
  • Int'l Joint Research
• [Presentation] 白金ナノコロイドを用いたユニバーサルボンドの象牙質接着強さ (2017)
  • Author(s): 勝俣 環,勝俣愛一郎,星加知宏,梶原武弘,佐野英彦,西谷佳浩
  • Organizer: 第14回日本再生歯科医学会学術大会
• [Presentation] 新規接着性レジンセメントを用いた象牙質とレジンブロックの微小引張接着強さについて (2017)
  • Author(s): 星加知宏,勝俣愛一郎,勝俣 環,西谷佳浩.
  • Organizer: 第146回日本歯科保存学会学術大会
• [Presentation] 新規亜鉛含有バイオアクティブガラスによる象牙質脱灰抑制効果の検討 (2017)
  • Author(s): 勝俣愛一郎,星加知宏,丁 群展,勝俣 環,西谷佳浩
  • Organizer: 第147回日本歯科保存学会学術大会
• [Presentation] ポルトランドセメント含有接着性根管充填用シーラーの細胞増殖への影響 (2017)
  • Author(s): 永山祥子,髙 裕子,勝俣愛一郎,梶原武弘,星加知宏,西谷佳浩
  • Organizer: 第147回日本歯科保存学会学術大会
• [Presentation] 新規接着性レジンシステムを用いた象牙質とコンポジットレジンの微小引張接着強さについて (2017)
  • Author(s): 星加知宏,勝俣愛一郎,丁 群展,勝俣 環,西谷佳浩
  • Organizer: 第147回日本歯科保存学会学術大会
• [Presentation] 接着性レジンセメントのガラスセラミックスにおける象牙質微小引張強さについて (2016)
  • Author(s): 星加知宏, 梶原武弘，達山祥子，徳田雅行，西谷佳浩
  • Organizer: 日本歯科保存学会2016年度秋季学術大会（第145回）
  • Place of Presentation: キッセイ文化ホール（長野県松本市水汲）
  • Year and Date: 2016-10-26
• [Presentation] The evaluation of new all-in-one self-etching adhesives. (2016)
  • Author(s): T. Hoshika, Y. Nishitani, K. Takahashi, T. Kajihara, M. Yoshiyama
  • Organizer: 94th General Session & Exhibition of the International Association for Dental Research
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-06-22
  • Int'l Joint Research
• [Presentation] 歯面処理方法の違いが新規ワンステップボンディング材の象牙質微小引張強さに及ぼす影響について. (2015)
  • Author(s): 星加知宏
  • Organizer: 第142回日本歯科保存学会学術大会
  • Place of Presentation: 福岡県北九州市小倉
  • Year and Date: 2015-06-25