The study of the hypoxia culture using human induced pluripotent stem cells

Research Project

Project/Area Number	15K20407
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Conservative dentistry
Research Institution	Nagasaki University
Principal Investigator	SUGIMOTO Koji 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (40646113)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	Hypoxia / Stat3 / ヒトiPS細胞 / HIF / 低酸素培養 / STAT3 / 低酸素 / HIFs
Outline of Final Research Achievements	This study indicates that the HIF-2α expression in human iPS cells was activated under hypoxic conditions, similarly to that in murine iPS cells, and that HIF-2α among HIFs is the most effective compound for maintaining the pluripotency of human iPS cells. Furthermore, the STAT3 signal pathway regulates the expression of HIF-2α.

Report

(4 results)