Development of pulp and hard tissue regeneration by the novel NF-kB inhibitor, MTI-II.
| Project/Area Number |
15K20409
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Conservative dentistry
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| Research Institution | Hiroshima University (2016)
Kyushu Dental College (2015) |
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Principal Investigator |
Tsuchiya Shizu 広島大学, 医歯薬保健学研究院(歯), 助教 (60610053)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 炎症 / 硬組織 / 炎症制御 / NF-κBシグナル / 炎症抑制 / 骨芽細胞分化 / 象牙芽細胞分化 |
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| Outline of Final Research Achievements |
We have previously reported that the inflammatory cytokine, tumor necrosis factor α (TNFα) inhibits BMP-induced osteoblast differentiation via NF-κB signaling. In the present study, we examined the effects of a steroid-coactivator, Macromolecular Translocation Inhibitor II (MTI-II), on inflammatory responses（Endocrinology, 2016）. MTI-II was previously demonstrated as an enhancer of the transcriptional activity of glucocorticoid-bound glucocorticoid receptor. We examined the effects of MTI-II on the inhibition of odontoblastogenesis by TNFα. When the cells were treated with TNFα, ALP activity was inhibited, while MTI-II restored TNFα-mediated inhibition of the activity in a dose-dependent manner (J Cell Biochem, 2016). MTI-II potentially acts as an anti-inflammatory drug.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] A small nuclear acidic protein (MTI-II, Zn2+-binding protein, parathymosin) that inhibits transcriptional activity of NF-κB and its potential application to anti-inflammatory drugs.2016
Author(s)
Okamoto K, Hirata-Tsuchiya S, Kitamura C, Omoteyama K, Sato T, Arito M, Kurokawa MS, Suematsu N, Kato T
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Journal Title
Endocrinology
Volume: 157(12)
Issue: 12
Pages: 4973-4986
DOI
Related Report
Peer Reviewed / Open Access
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