The Expression and function of Forkhead Transcription Factor of the class O3a (Foxo3a)
| Project/Area Number |
15K20415
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Conservative dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 歯根肉芽腫 / Foxo3a / Fas-ligand / FAS-L |
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| Outline of Final Research Achievements |
Two-color immunofluorescense image analysis indicate that co-expression of Foxo3a and Fas-L in human periapical granulomas. Neutrophils, lymphocytes, and plasma cells in periapical granulomas expressed Foxo3a but not those in healthy gingival tissues. uantitative analysis of immunofluorescence signals indicated significantly greater numbers of Foxo3a-expressing than FasL-expressing cells. Foxo3a and FasL messenger RNA expression levels in periapical granulomas were significantly higher than those in healthy gingival tissues. In addition, the Foxo3a messenger RNA expression in stimulated human T-cell line(Molt-4) for 72 hours was significantly higher than negative control. Our results indicated the possibility that Foxo3a and FasL are involved in the development and healing of periapical granulomas.
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Report
(4 results)
Research Products
(14 results)
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[Book] 抜髄 Initial Treatment 治癒に導くための歯髄への臨床アプローチ2016
Author(s)
興地隆史, 新井恭子, 小木曾文内, 佐藤勧哉, 大島勇人, 松浦信幸, 泉英之, 北村和夫, 澁川義幸, 長谷川誠実, 阿部修, 吉川剛正, 田崎雅和, 清水康平, 加藤広之, 田中利典, 村松敬, 羽鳥啓介, 澤田則宏, 石井宏, 五十嵐勝, 大原絹代, 佐藤暢也, 清水花織, 北島佳代子, 篠田雅路, 岩波洋一
Publisher
HYORON
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