Bactericidal action of photodynamic antimicrobial chemotherapy (PACT) with photosensitizers used as plaque disclosing agents
Project/Area Number |
15K20424
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Prosthodontics/ Dental materials science and
|
Research Institution | Tohoku University |
Principal Investigator |
Ishiyama Kirika 東北大学, 歯学研究科, 教育研究支援者 (20712904)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | PACT / 光線力学療法 / バイオフィルム / 殺菌 / ローズベンガル / ポリフェノール / カフェイン酸 / 光線力学殺菌療法 |
Outline of Final Research Achievements |
The present study demonstrated that photodynamic antimicrobial chemotherapy (PACT) using rose bengal as a photosensitizer was effective against planktonic bacteria. However, the antimicrobial activity against biofilm was considerably low. In contrast, antimicrobial chemotherapy based on UVA irradiation of caffeic acid aqueous solution showed high bactericidal effect against Streptococcus mutans biofilm. Caffeic acid is a kind of polyphenols and contained in various fruits and vegetables. This indicates that remaining caffeic acid after treatment may not be toxic when this antimicrobial technique is used in oral cavity. In addition, wounded skin irritation test using rats showed that the treatment did not deter the healing process. Therefore, it is suggested that the UVA irradiation of polyphenols be more suitable for dental application than PACT.
|
Report
(4 results)
Research Products
(2 results)