| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The present study demonstrated that photodynamic antimicrobial chemotherapy (PACT) using rose bengal as a photosensitizer was effective against planktonic bacteria. However, the antimicrobial activity against biofilm was considerably low. In contrast, antimicrobial chemotherapy based on UVA irradiation of caffeic acid aqueous solution showed high bactericidal effect against Streptococcus mutans biofilm. Caffeic acid is a kind of polyphenols and contained in various fruits and vegetables. This indicates that remaining caffeic acid after treatment may not be toxic when this antimicrobial technique is used in oral cavity. In addition, wounded skin irritation test using rats showed that the treatment did not deter the healing process. Therefore, it is suggested that the UVA irradiation of polyphenols be more suitable for dental application than PACT.
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