| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The purpose of this study is to define a muscle activity model with HDC activity as an indicator to elucidate fatigue and pain due to sustained muscle activity and to elucidate the mechanism of IL-1β -HDC - histamine as a chronic pain inducing factor according to the degree of muscle activity. As a result of forced walking experiments, there were many mice with IL - 1 - KO mice falling out, but no significant difference in HDC activity was observed. There was no significant difference in HDC activity due to low intensity electrical stimulation. No significant difference was obtained in the experiment by the von Frey test after forced walking. No significant difference was found in the masseter muscle activity 2 hours after administration of the masseter muscle of the NGF, but the masseter muscle activity tended to decrease after 1 day.
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