Neuroscientific analyses of ameliorative effects of mastication on depression and hart desease

• Project/Area Number: 15K20459
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Kanagawa Dental College
• Principal Investigator: Yamada Kentaro 神奈川歯科大学, 歯学部, 非常勤講師 (10550816)
• Research Collaborator: YAMAMOT Toshiharu
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 扁桃体 / 咀嚼運動 / 中脳中心灰白質 / 島皮質 / チューイング / ストレス緩和作用 / 帯状回 / 咀嚼 / 抑うつ / 心疾患

Outline of Final Research Achievements

Chewing under stress suppressed the increase of stress-responding neurons in the insular cortex and periaqueductal grey matter that regulate circulatory system through the reticular formation of the medulla oblongata. This suggests the presence of possibility that chewing ameliorates heart disease. In addition, we demonstrated that chewing under stress increased GABA (gamma aminobutylic acid) efflux in the amygdala. The amygdala has inter-connections with the prefrontal cortex and hippocampus that relate with depression. This suggests that chewing may be able to ameliorate depression.

Research Products

• [Journal Article] Chewing ameliorates the effects of restraint stress on pERK-immunoreactive neurons in the rat insular cortex (2018)
  • Author(s): Masami Onuki, Toshiharu Yamamoto, Kenichi Sasaguri, Kentaro Yamada, Naruo Okada, Toshitsugu Kawata
  • Journal Title: Neuroscience Letters Volume: 674 Pages: 60-65
  • DOI: 10.1016/j.neulet.2018.03.008
  • Peer Reviewed
• [Journal Article] Uncovering the neural circuitry involved in the stress-attenuation effects of chewing (2018)
  • Author(s): Kenichi Sasaguri, Kentaro Yamada, Toshiharu Yamamoto
  • Journal Title: Japanese Dental Science Review Volume: 未定 Issue: 3 Pages: 118-126
  • DOI: 10.1016/j.jdsr.2018.03.002
  • NAID: 210000183916
  • Peer Reviewed / Open Access
• [Journal Article] Stress-induced galectin-1 influences immune tolerance in the spleen and thymus by modulating CD45 immunoreactive lymphocytes. (2017)
  • Author(s): .Sasaguri K, Yamada K, Narimatsu Y, Oonuki M, Oishi A, Koda K, Kubo KY, Yamamoto T, Kadoya T.
  • Journal Title: J Physiol Sci. Volume: 67(4) Issue: 4 Pages: 489-496
  • DOI: 10.1007/s12576-016-0478-8
  • NAID: 40021238379
  • Peer Reviewed / Open Access
• [Journal Article] CXCL14-like Immunoreactivity Exists in Somatostatin-containing Endocrine Cells, and in the Lamina Propria and Submucosal Somatostatinergic Nervous System of Mouse Alimentary Tract (2017)
  • Author(s): Suzuki H, Yamada K, Matsuda Y, Onozuka M, Yamamoto T
  • Journal Title: ACTA HISTOCHEMICA ET CYTOCHEMICA Volume: 50 Issue: 6 Pages: 149-158
  • DOI: 10.1267/ahc.17015
  • NAID: 130006285160
  • ISSN: 0044-5991, 1347-5800
  • Peer Reviewed / Open Access
• [Journal Article] Glucose transporter 5 (GLUT5)-like immunoreactivity is localized in subsets of neurons and glia in the rat brain (2016)
  • Author(s): Akiko Kojo, Kentaro Yamada, Toshiharu Yamamoto
  • Journal Title: Journal of Chemical Neuroanatomy Volume: 74 Pages: 55-70
  • DOI: 10.1016/j.jchemneu.2016.03.004
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Chewing suppresses the stress-induced increase in the number of pERK-immunoreactive cells in the periaqueductal grey (2015)
  • Author(s): Kentaro Yamada, Yuri Narimatsu, Yumie Ono, Ken-ichi Sasaguri, Minoru Onozuka, Toshitsugu Kawata, Toshiharu Yamamoto
  • Journal Title: Neuroscience Letters Volume: 599 Pages: 43-48
  • DOI: 10.1016/j.neulet.2015.05.023
  • Peer Reviewed / Open Access
• [Presentation] チューイングはラット島皮質における拘束ストレス誘導性pERKの増加を抑制する (2016)
  • Author(s): 大貫真美、笹栗健一、山本利春、山田健太朗、河田俊嗣
  • Organizer: 日本矯正歯科学会
  • Place of Presentation: 徳島
  • Year and Date: 2016-11-07