| Project/Area Number |
15K20493
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Dental engineering/Regenerative dentistry
|
|---|
| Research Institution | Aichi Gakuin University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 再生歯学 / 組織工学 / Ar-PVDCフィルム / 骨再生誘導 / 細胞遊走 / 骨分化誘導 / 骨欠損モデルの作成 / 細胞移植法の確立 / 異所性骨形成の未確認 / Ar-PVDC上での骨分化 / 大腿骨欠損モデルの作成 / 細胞遊走の確認 |
|---|
| Outline of Final Research Achievements |
The purpose of this study is to promote bone defect healing using composite of osteoblast and Ar-modified Polyvinylidene chloride (Ar-PVDC) film. First, the alkaline phosphatase (ALP) activity on Ar-PVDC was assessed for differentiation. The ALP activity of osteoblast was enhanced on Ar-PVDC than that of PVDC.
Next, composite of osteoblast and Ar-PVDC film was transplanted in bone defect of rat femur. However, there is no difference between Ar-PVDC and Ar-PVDC. This result suggest that the osteoconductivity of Ar-PVDC is high.
|
