| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In this study, we examined whether transplanted-DPSCs produce new bone and improve diabetic polyneuropathy. Rat-derived DPSCs were injected into a critical-sized bone on carvalial bone. The transplantation of DPSCs with Collagen showed bone formation starting from the edges as well as from the center of the defect. Human-derived DPSCs were injected into unilateral hindlimb skeletal muscles of streptozotocin-induced diabetic mouse. The transplantation of DPSCs improved the impaired sciatic nerve conduction velocity, sciatic nerve blood flow and sentation. These results revealed that DPSCs may be an effective regenerative therapy on bone and nerve tissue.
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